| 杨振国,王德文,宋良文,等.吸入一氧化氮防治放射性间质肺炎疗效观察[J].中华放射医学与防护杂志,2002,22(4):288-290.YANG Zhenguo,WANG Dewen,SONG Liangwen,et al.lnhaling nitric oxide to prevent and cure radiation interstitial pneumonia[J].Chin J Radiol Med Prot,2002,22(4):288-290 |
| 吸入一氧化氮防治放射性间质肺炎疗效观察 |
| lnhaling nitric oxide to prevent and cure radiation interstitial pneumonia |
| 投稿时间：2001-09-21 |
| DOI： |
| 中文关键词: 一氧化氮 放射性间质肺炎 |
| 英文关键词:Nitric oxide Radiation interstitial pneumonia |
| 基金项目:国家自然科学基金资助项目(29807213) |
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| 中文摘要: |
| 目的 观察吸入一氧化氮对放射性间质性肺炎的防治效果,以期探索防治放射性肺炎的新措施。方法 建立放射性肺纤维化动物模型,分别在照前1d(B和C组)及照后1个月(D和E组)开始吸入NO,每种方式均持续治疗1个月,NO吸入浓度为20×10-6(B和D组)和10×10-6(C和E组)两个剂量,单纯照射组(A组)和正常对照组(F组)不加任何处理。分别于照射后1d、1周、1个月、3个月和6个月取材观察。结果 动物死亡率B组(10%)和C组(5%)低于其他各组;照射后1个月,肺重与体重之比B组和C组低于A组(P<0.05);照后6个月,A组呈现局灶性纤维化;B和C组主要在肺叶顶部可见局灶性增生和轻度纤维化病变;D和E组可见有较大面积的增生灶,主要集中在肺叶顶部。结论 照射前吸N0明显减轻放射性急性间质肺炎的发生及其病变程度,降低动物死亡率,延缓和减轻肺纤维化发生的时间和程度,而照射后吸入NO此种作用较弱。 |
| 英文摘要: |
| Objective To investigate the effect of inhaling nitric oxide to prevent and cure radiation interstitial pneumonia. Methods The whole rat thorax of all rats was irradiated with 30 Gy 60 Co γ rays and a pulmonary fibrosis model was made at month 3 after irradiation.The starting time of inhaling NO was one day before (B and C groups) or one month after (D and E groups) irradiating, respectively, and the duration of inhalation was one month for every group.The concentration of NO inhaled was 20 ppm (B and D groups) and 10 ppm (C and E groups). Group A was not treated with NO.The lung specimens were harvested 1 w, 1 m, 3 m and 6 m after irradiation. Results Mortalities of group B and group C were 10% and 5%, respectively, which were lower than that of group A (22.6%), group C(34.3%) and group D(14%).Acute interstitial pneumonia was observed in each group at 1 month after irradiation.But the inflammatory reaction and tissue damage in group B and C were slighter than other groups.The ratio of lung weight to body weight in group A was higher than that of groups B and C (P <0. 05).At month 6 after irradiation, patches of fibrosis were formed in group A, which was mainly found around bronchi blood vessels and the apex of lungPO 2 was decreased in group A significantly compared with other groups(P <0.05).In groups B and C slight focal hyperplasia and fibrosis were found in the apex of lung.In groups D and E, large areas of proliferation were seen, and mainly in the apex of lung. Conclusion By inhaling NO before irradiation, the radiation interstitial pneumonia can be attenuated, mortality decreased, and fibrosis delayed and reduced.For inhalation of NO after irradiation, the effect will be decreased. |
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