| 王作元,Lubin JH,王陇德,张守志,Boice JD Jr,崔宏星,张淑蓉,Conrath SC,夏英,尚兵,BrennerA,雷苏文,Metayer KC,曹吉生,Chen KW,雷淑杰,Kleinerman RA.室内氡与肺癌关系研究[J].中华放射医学与防护杂志,2002,22(3):209-214 |
| 室内氡与肺癌关系研究 |
| Relation between indoor radon and lung cancer |
| 投稿时间：2001-07-16 |
| DOI： |
| 中文关键词: 照射 误差 肺癌 辐射 氡 |
| 英文关键词:Exposure Errors Lung cancer Radiation Radon |
| 基金项目:美国国立卫生研究院资助项目(NO1CP50509) |
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| 中文摘要: |
| 目的 直接调查居室水平氡浓度对居民肺癌危险度的影响,并与由矿工受照结果推导的结论相比较。方法 在甘肃省平凉、庆阳两地区进行病例对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在1994年1月至1998年4月期间诊断,年龄在30～75岁之间,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照,对照要在年龄、性别、地区方面与病例相匹配。在过去5～30年期间,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了77%的照射周期。结果 病例居室的平均氡浓度为230.4Bqm3(n=768),对照为222.2Bqm3(n=1659).居民肺癌危险度随室内氡水平的增高有所上升(P<0.001).根据线性模型,对全部研究个体而言,在100Bqm3情况下,附加比值比(EOR)为0.19(95%CI:0.05,0.47).对测量涵盖了100%照射周期的个体,为0.31(95%CI:0.10,0.81).在对照射的不确定度进行调整后,估算值可增加70%.结论 研究结果证明室内水平氡照射会增加肺癌危险度,增加值等于或超过从矿工数据外推的结果。 |
| 英文摘要: |
| Objective Low level of exposures to residential radon and dosimetric uncertainties due to mobility have hampered the evaluation of lung cancer risk and the comparison to radonexposed miners.To address these limitations,the authors conducted a casecontrol study in a predominantly rural area of China with low mobility and high radon levels.Methods Cases studied including all lung cancer patients diagnosed between Ja nuary 1994 and April 1998,aged 30-75 years,and resided in two prefectures of Gansu Province.Controls were randomly selected from census lists and matched on age sex and prefecture.Radon detectors were placed in all houses having been occupied two or more years in the past 530 years prior to enrollment.Measurements covered 77% of the possible exposure time.Results Mean radon concentrations were 230 4 Bq/m3 for the cases( n =768) and 222.2 Bq/m3 for the controls( n =1 659).Lung cancer risk increased along with increase of the radon level( P <0.001).Based on a linear model,the excess odds ratio(EOR)at 100 Bq/m3 was 0.19(95% CI:0.05,0 47)for all subjects,and 0.31(95%CI:0.10,0.81)for subjects with 100% coverage of the exposure interval.Adjusting for exposure uncertainties increased estimates about 70%.Conclusion The results support increased lung cancer risks with indoor radon exposures,which may equal to or exceed extrapolationbased risks from miner data. |
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