| 艾国平,粟永萍,阎国和,等.骨髓间充质干细胞对放创复合伤创面的促愈作用[J].中华放射医学与防护杂志,2002,22(3):164-167.AI Guoping,SU Yongping,YAN Guohe,et al.Effects of bone marrow mesenchymal stem cells on healing of wound combined with local radiation injury[J].Chin J Radiol Med Prot,2002,22(3):164-167 |
| 骨髓间充质干细胞对放创复合伤创面的促愈作用 |
| Effects of bone marrow mesenchymal stem cells on healing of wound combined with local radiation injury |
| 投稿时间：2001-11-19 |
| DOI： |
| 中文关键词: 间充质干细胞 放创复合伤创面 组织修复 |
| 英文关键词:Mesenchymal stem cells Wound combined radiation injury Healing of wounded tissue |
| 基金项目:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
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| 中文摘要: |
| 目的 探讨骨髓间充质干细胞对放创复合伤创面的促愈作用。方法 利用自体骨髓来源的间充质干细胞移植于局部合并放射损伤的创面,采用荧光示踪技术、形态学观察、胶原染色、成纤维细胞和毛细血管计数、羟脯氨酸含量测定等多种指标,观察了间充质干细胞对放创复合伤创面的促愈作用。结果 间充质干细胞能加快创面愈合,促进肉芽组织生长和胶原合成。结论 骨髓间充质干细胞对放创复合伤创面有明显的促愈效应。 |
| 英文摘要: |
| Objective To explore the effects of bone marrow mesenchymal stem cells(MSC) on healing of wounds combined with local skin irradiation injury.Methods MSC were injected into the wound combined with local skin irradiation injury.Light and electron microscopy,fibroblast and capillary vessel counts,detection of hydroxyproline content in the wound and demonstration of MSC distribution by fluorescence examination were carried out.Results MSC could accelerate the speed of wound healing,The number of fibroblasts and capillary vessels increased obviously during 5 to 20 days after wounding.Granular tissues were abundant in the wound,and the content of hydroxyproline increased in the MSC treated groups.The fluorescence labeling showed that MSC could be found during 1 to 20 days after injection.Conclusion MSC can remain alive in the wound for a long time and surely promote wound healing. |
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