| 冉新泽,程天民,林远,等.全身放射损伤影响皮肤创伤愈合的剂量效应研究[J].中华放射医学与防护杂志,2002,22(3):149-152.RAN Xinze,CHENG Tianmin,LIN Yuan,et al.Dose-effect relationships of total-body irradiation on healing of cutaneous wound[J].Chin J Radiol Med Prot,2002,22(3):149-152 |
| 全身放射损伤影响皮肤创伤愈合的剂量效应研究 |
| Dose-effect relationships of total-body irradiation on healing of cutaneous wound |
| 投稿时间：2001-11-19 |
| DOI： |
| 中文关键词: 放射损伤 放创复合伤 创伤愈合 剂量效应 |
| 英文关键词:Radiation injury Combined radiation-trauma injury Wound healing Dose-effect |
| 基金项目:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
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| 中文摘要: |
| 目的 探讨全身不同剂量照射对皮肤软组织创伤愈合的剂量效应关系。方法 用60Coγ射线一次性均匀照射1～8Gy,照后1h内,用特制的圆孔刀致大鼠背部全层皮肤22mm创面2个(占体表面积的25%).结果 创伤合并0、1、2、3、4、5、6、7、8Gy全身照射后,随照射剂量增加,创伤愈合速度明显减缓,残留面积明显增大,如伤后7d,单创组有33.5%的创面未愈合,复合伤组分35.4%,38.1%,41.6%,48.8%,53.9%,63.7%,69.2%,73.9%的创面未愈合。统计学显示,伤后不同剂量与未愈合创面%(Ý)间有明显的剂量效应关系。据此推导出9个剂量效应公式。这些结果主要为群体判估放创复合伤伤情发展提供了重要基础数据。结论 放创复合伤时创伤愈合延迟有明显的剂量效应关系。 |
| 英文摘要: |
| Objective To study the effects of dosage of totalbody irradiation on healing process of cutaneous wound.Methods Rats were irradiated with a 60Co γray source.The single dosage varied from 1 to 8 Gy.Within 1 h after irradiation,two full thickness circular wounds (22 mm) were produced on the back of animals,corresponding to 2.5% of total body surface area.Results After totalbody irradiation with 1,2,3,4,5,6,7,8 Gy combined with cutaneous wound,the rate of healing was obviously retarded along with the increase of irradiation dose.The surface of the wound remained was larger in the high dosage group as compared to that of the lower dosage ones.Taking 7 d after injury for example,there was 35.5% wound surface left unhealed in rats of the group with cutaneous wound only,while in the combined injury groups irradiated with 1 to 8 Gy,there were 35.4%,38.1%,41.6%,48.8%,53.9%,63.7%,69.2%,73.9% remained unhealed,respectively.Statistical analysis showed that there were marked correlation between irradiation dosage and the percentage of unhealed wound surface (Ý).Nine doseeffect relation formulas were derived according to the statistical results.Conclusion For soft tissue trauma combined with radiation injury,the delay of wound healing is definitely related to the dose of radiation inflicted. |
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