| 高亚兵,杨瑞彪,彭瑞云,等.γ射线照射对兔眼损伤效应的实验研究[J].中华放射医学与防护杂志,2002,22(1):32-34.,et al.Effect of glucagon-like peptide 2 on recovery of intestinal function from radiation injury in mice[J].Chin J Radiol Med Prot,2002,22(1):32-34 |
| γ射线照射对兔眼损伤效应的实验研究 |
| Effect of glucagon-like peptide 2 on recovery of intestinal function from radiation injury in mice |
| 投稿时间：2001-01-08 |
| DOI： |
| 中文关键词: 胰高血糖素样肽-2 放射损伤 小肠功能 小鼠 |
| 英文关键词:Glucagon-like peptide 2 Radiation injury Intestinal function Mice |
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| 中文摘要: |
| 笔者系统地动态研究了60Coγ射线照射对兔眼的急性损伤、剂量与效应关系和病理学变化特点, 试图阐明眼辐射损伤的临床表现、病变规律和损伤机理, 为进一步研究放射性白内障和角膜损伤的发生规律、机理以及防治提供实验依据。一、材料和方法1.实验动物与分组：青紫蓝灰兔114只, 体重为1.5～2.5kg.照射前外眼检查, 复方托品酰胺扩瞳检查晶状体、眼底、玻璃体无病变者, 按吸收剂量随机分为5组：2Gy(18只)、10Gy(26只)、20Gy(26只)、30Gy(26只)组和对照组(18只)。 |
| 英文摘要: |
| Objective To investigate the effect of glucagon-like peptide 2(GLP-2) on recovery of intestinal epithelial function from radiation injury in mice. Methods Kunming mice received a single dose of 8 Gy total-body irradiation from 60 Co gamma-rays followed by treatment with GLP-2 or vehicle.Intestinal permeability, plasma endotoxin content, glucose absorption, and sucrase and lactase activities were measured on days 1, 3, 5 after treatment. Results In irradiated mice intestinal permeability and glucose absorption were significantly higher, and sucrase and lactase activities lower than those in normal mice on days 1, 3, 5(P<0.01 or P<005).Plasma endotoxin content in irradiated mice on days 1, 3 was significantly higher than that in the normal mice (P<0.01 or P<0.05).In GLP-2-treated mice, intestinal permeability, glucose absorption, and plasma endotoxin content restored to normal on day 3 sucrase and lactase activities restored to normal on day 5. Conclusion GLP-2 can promote recovery of intestinal mucosal barrier function, digestion and absorption function from radiation injury. |
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