| 陈检芳,周平,郑颂阳,等.锌和维生素E对肝辐射损伤脂质过氧化和膜流动性的影响[J].中华放射医学与防护杂志,2002,22(1):22-24.CHEN Jianfang,ZHOU Ping,ZHENG Songyang,et al.Effect of zinc and vitamin E on lipid peroxidation and membrane fluidity in liver with radiation injury[J].Chin J Radiol Med Prot,2002,22(1):22-24 |
| 锌和维生素E对肝辐射损伤脂质过氧化和膜流动性的影响 |
| Effect of zinc and vitamin E on lipid peroxidation and membrane fluidity in liver with radiation injury |
| 投稿时间：2001-05-06 |
| DOI： |
| 中文关键词: 锌 维生素E 肝 辐射损伤 膜流动性 小鼠 |
| 英文关键词:Zinc Vitamin E Liver Radiation injury Membrane fluidity Mice |
| 基金项目:湖南省卫生厅基金资助项目(9804) |
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| 中文摘要: |
| 目的 探讨Zn和VE在抗肝辐射损伤中的作用。方法 小鼠经60Coγ射线7.5Gy一次全身照射后, 及时给予微量元素Zn和VE治疗。测定其肝组织匀浆中LPO含量, GSHPx活力与线粒体、微粒体膜的流动性变化。结果 小鼠经辐射损伤后, 肝组织中LPO显着性升高, GSHPx活力明显下降；同时伴有膜流动性的改变。结论 Zn和VE有阻止脂质过氧化, 增加GSHPx的活力, 提高膜流动性作用, 在抗肝辐射损伤的保护性治疗中具有重要意义。 |
| 英文摘要: |
| Objective To evaluate the effect of zinc and vitamin E on protecting liver from radiation damage. Methods After a single 7.5 Gy whole-body irradiation by 60 Co gamma rays mice were fed with zinc and vitamin E,then LPO concentration and GSH-Px activity in liver homogenate were tested and changes of membrane fluidities in mitochondria and microsome were observed. Results After irradiation,the LPO concentration in liver homogenate increased significantly,whereas the activity of GSH-Px decreased.There were changes of membrane fluidities in both mitochondria and microsomes. Conclusions Zinc and vitamin E can inhibit lipid peroxidation and increase the activity of GSH-Px and membrane fluidity.They might have great potenials in protection against hepatic radiation injury. |
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