| 冉新泽,刘贤华,王东海,等.早期切痂对重度放烧复合伤大鼠的影响[J].中华放射医学与防护杂志,2002,22(1):17-19.RAN Xinze,LIU Xianhua,WANG Donghai,et al.Effects of early escharectomy on rats with combined radiation-burn injury[J].Chin J Radiol Med Prot,2002,22(1):17-19 |
| 早期切痂对重度放烧复合伤大鼠的影响 |
| Effects of early escharectomy on rats with combined radiation-burn injury |
| 投稿时间：2001-03-20 |
| DOI： |
| 中文关键词: 放烧复合伤 早期切痂创面愈合 |
| 英文关键词:Combined radiation-burn injury Early escharectomy Wound healing |
| 基金项目:全军医药卫生“九五”攻关课题基金资助项目(96L045) |
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| 中文摘要: |
| 目的 探讨早期切痂对放烧复合伤大鼠存活以及创面愈合的影响, 为临床治疗提供依据。方法 60Coγ射线全身照射5Gy,而后用5kW溴钨灯光辐射致10%Ⅲ度烧伤。伤后给予抗休克、抗感染, 伤后24h进行早期切痂缝合或保痂等治疗, 观察60d存活率、创面愈合时间以及体重变化等。结果 早期切痂缝合组60d存活率达78%,创面无感染、愈合好, 体重恢复快；明显高于不切痂组的40%(P<0.05),更高于切痂不缝合组的15%(P<0.01)和对照组的10%(P<0.01).结论 早期切痂缝合术在本伤情下是有效的, 也是可行的, 手术时机以伤后24～48h为宜。 |
| 英文摘要: |
| Objective To provide evidence for beneficial effect of clinical therapy with early escharectomy on survival and wound healing in rats with combined radiation-burn injury. Methods Rats were exposed to 5 Gy whole-body γ-ray irradiation from a 60 Co source and to thermal-radiation burn(10% TBSA,full thickness burn)successively by a 5 kW bromotungsten lamp.Then the animals were given anti-shock and anti-infection remedies.Early escharectomy and stitch(EES) at 24 h after injury,eschar-protecting treatment,or other treatment modarlities were carried out.The 60-day survival rate,the duration of wound healing and the changes of the body weight of animals were observed. Results The 60-day survival rate of EES group reached 78%,being higher than that of the no-escharectomy group(40%,P<0.05)and even higher than that of the escharectomy with non-stitch group(15%,P<0.01)and that of the control group(10%,P<0.01).Besides,in the EES group,the wound showed no sign of infection and healed well,and the body weights recovered faster. Conclusions EES is effective and available on this model of combined injuries.It is appropriate for operation at 24-48 h after injury. |
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