| 舒崇湘,叶本兰,程天民,等.5 Gy全身辐射对创伤伤口巨噬细胞离子通道活动的影响及W11-a12的作用[J].中华放射医学与防护杂志,2001,21(6):417-420.SHU Chongxiang,YE Benlan,CHENG Tianmin,et al.Effects of 5 Gy total-body irradiation and W11-a12 on ion channels of wound macrophages[J].Chin J Radiol Med Prot,2001,21(6):417-420 |
| 5 Gy全身辐射对创伤伤口巨噬细胞离子通道活动的影响及W11-a12的作用 |
| Effects of 5 Gy total-body irradiation and W11-a12 on ion channels of wound macrophages |
| 投稿时间：2000-10-24 |
| DOI： |
| 中文关键词: 辐射 创伤愈合 巨噬细胞 离子通道 多元醇化合物 |
| 英文关键词:Irradiation Wound healing Macrophage Anion selective channel W11-a12 |
| 基金项目:国家973基础重点研究发展规划资助项目(G1999054205);重庆市科委院士基金资助项目(98-5081) |
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| 中文摘要: |
| 目的 探讨电离辐射对伤口巨噬细胞(MΦ)离子通道活动的影响及W11a12对其的作用。方法 采用电生理膜片钳cell-attached离子单通道记录方法。结果 与单伤组相比,复合伤组伤口MΦ的通道自发性开放的细胞数显着降低;以氯离子为载体的阴离子通道及以钾离子为载体的阳离子通道表现为开放概率降低;平均开放时间常数缩短;平均关闭时间常数延长。W11-a12能增加两伤类组伤口MΦ氯、钾离子通道自发开放。结论 电离辐射抑制MΦ膜上离子通道的活动可能是其抑制MΦ功能的一个重要途径。W11-a12可减弱电离辐射的这一抑制作用。 |
| 英文摘要: |
| Objective To study the effects of irradiation and W11-a12,a kind of repair promoting drug,on ion channels in membrane of macrophages from wound. Methods The activity of ion channel was recorded from cell-attached patches with patch clamp techniques. Results The effects of irradiation on ion channel in membranes of wound macrophages include:①decreasing the mean number of cells with ion channel openning spontaneously;②depressing the opening of Cl- and potassium channels by decreasing open-state probability,shortening open-time and prolonging close time.The effects of irradiation could be partly depressed by W11-a12. Conclusion Irradiation will depress the ion channel of macrophages from wound,which may be an important way in its depressing the function of macrophage. |
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