| 鞠永健,孙福印,苑淑渝,等.放射性药物内照射治疗后肿瘤控制概率计算模型的研究[J].中华放射医学与防护杂志,2001,21(5):367-370.JU Yongjian,SUN Fuyin,YUAN Suyu,et al.Research on calculation modes of tumor control probability following internal radionuclide therapy[J].Chin J Radiol Med Prot,2001,21(5):367-370 |
| 放射性药物内照射治疗后肿瘤控制概率计算模型的研究 |
| Research on calculation modes of tumor control probability following internal radionuclide therapy |
| 投稿时间：2000-12-13 |
| DOI： |
| 中文关键词: 肿瘤控制概率 辐射敏感性 放射性药物内照射治疗 克隆源性细胞 |
| 英文关键词:Tumor Control Probability Radiosensitivity Internal radionuclide therapy Clonogen |
| 基金项目:国家自然科学基金资助项目(39670228);卫生部课题资助项目(981043) |
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| 中文摘要: |
| 目的 导出一个考虑剂量及生物学影响因素、能计算放射性药物内照射治疗后肿瘤控制概率(TCP)的模型.方法 参考现有的放射治疗TCP模型(模型1和2)、细胞存活率模型,导出依赖于剂量、辐射敏感性、DNA单链断裂修复等因素的内照射治疗后的TCP计算模型(模型3),然后在同一治疗条件下以核素32P为例,用模型3和模型1、2分别进行计算并对结果进行比较.结果 在假设的参数条件下,模型3所算得的给定治疗活度时的可治疗的肿瘤半径范围最小且点源时与实验结果最接近、活度无穷大时其最大限度的治疗半径最小且点源时与核素的最大射程吻合,要比模型1、2算得的结果更接近于实际情况.结论 模型3比较全面地考虑了涉及的因素,可用于肿瘤的TCP值计算,以作为评估计划及预测结果的依据. |
| 英文摘要: |
| Objective To construct a calculation model of tumor control probability (TCP) with consider ation of the effect of dose and biological factors,It's expected that the result calculated by the model following internal radionuclide therapy would be appropriate to the actual value. Methods Referring to the TCPmodels of radiotherapy and the models of cell survival rate reported by other authors,a TCPmodel (model 3) following internal radionuclide therapy,which considered the effect factors of dose,repair of DNAsingle strand damage,radiosensitivity has been set up.Then using nuclide 32 Pas an example,model 3 will be compared with the other two models (model l and 2) by calculation the TCPvalue under the same treatment conditions. Results Compared with model 1 and 2,the result calculated by model 3 shows that:1.With a certain treatment activity (37×107 Bq),the radius of tumor which can be cured is closer to the experiment result.2.If the given activity is infinitely great,the largest tumor radius which can be cured is smaller and coincide with the largest range of nuclide32 P.So the result calculated by model 3 is fitter with the actual value than that calculated by the other two models. Conclusion The model 3 has considered more factors than others,so if the biological parameters are known,it could be used to calculate the TCPvalue under a certain kind of treatment condition to predict the internal radionuclide therapy result and estimate whether the treatment plan is reasonable. |
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