| 刘玉龙,周剑影,王国权,戴宏,段莹莹,郭晓葵,李元.人重组白细胞介素-8(rhIL-8)对受照小鼠抗放作用的实验研究[J].中华放射医学与防护杂志,2001,21(4):241-243 |
| 人重组白细胞介素-8(rhIL-8)对受照小鼠抗放作用的实验研究 |
| Experimental study of radioprotective effects of rhIL-8 on irradiated mice and its mechanism |
| 投稿时间：2001-04-30 |
| DOI： |
| 中文关键词: 白细胞介素-8 BALB/c小鼠 放射损伤 |
| 英文关键词:Interleukin-8 BALB/c mouse Radiation injury |
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| 中文摘要: |
| 目的 研究rhIL-8对放射损伤小鼠的保护作用及其机理.方法 在小鼠受照前不同时间给予腹腔注射rhIL-810 μg或 30 μg,观察动物的存活情况及一些指标. 结果 小鼠受照后的存活时间与rhIL-8的给药剂量及时间密切相关.通过检测受照后小鼠的骨髓细胞CUF GM计数、血清总SOD活性及MDA含量以及一些免疫功能指标,提示它们与动物的存活时间有内在联系.结论rhIL-8具有一定的抗放作用,其机理可能与造血调控、免疫调控、清除自由基等多方面有关. |
| 英文摘要: |
| Objective To study the radioprotective effects of rhIL-8 on irradiated mice and its mechanism. Methods Single intraperitoneal injections of rhIL-8 at 10 μg or 30 μg at different times to BALB/c mice before they were exposed to 8.5 Gy or 6.5 Gy 6 MV X-rays.The survival state of mice and some monitoring indices were observed. Results The survival times of irradiated mice were closely related to the dose lever of rhIL-8 and the injection time.CFU-GM counts of bone marrow cells,serum total contents of superoxide dismutase (T-SOD) and malondialdehyde (MDA),and immunity function indices were examined in all mice at six days after expousure 6.5 Gy 6 MV X-rays.It is showed that the examination findings and the survival state of irradiated mice were interrelated with one another. Conclusion rhIL-8 has certain radioprotective effects through complex mechanisms of modulation of hematopoiesis, immuno-modulation,clearance of free radicals,etc. |
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