| 孙苏平,蔡建明,项莺松,赵芳,黄定德,高建国,杨如俊.不同细胞量异基因小鼠骨髓移植回巢规律的实验研究[J].中华放射医学与防护杂志,2001,21(2):87-89 |
| 不同细胞量异基因小鼠骨髓移植回巢规律的实验研究 |
| Homing regularity of different doses bone marrow transplantation in allogeneic hosts |
| 投稿时间：2000-05-20 |
| DOI： |
| 中文关键词: 异基因小鼠 骨髓移植 回巢 回巢率 |
| 英文关键词:Allogeneic mouse Bone marrow transplantation Homing Homing efficiency |
| 基金项目:国家自然科学基金资助项目(39770329,3960077) |
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| 中文摘要: |
| 目的 探讨不同细胞量骨髓移植的回巢规律,进一步提高移植效果。方法 采用异基因小鼠模型进行不同细胞量骨髓移植,观察了不同细胞量组及其在不同时间点的回巢情况。结果 回巢的阳性细胞比例：不同细胞量组之间的差别无统计学意义；不同时间点以第3天最高(P<0.01).从外周血、骨髓、脾的供体阳性细胞和回巢率的变化中可看到供体细胞在受体体内有回巢出巢再回巢的现象。回巢率：骨髓低细胞量组的回巢率高于高细胞量组(P<0.01),不同时间点和脾各组间回巢率差异无显着性,脾各时间点回巢率差异具有显着性(P<0.05).结论 在一定细胞量范围内低细胞量组的回巢率高于高细胞量组,一次性大量移植可能是一种浪费。 |
| 英文摘要: |
| Objective To explore the homing regularity of different doses of bone marrow cell transplantation.Method An allogeneic mouse model was used in this study.The homing status of different dose groups from the first day to the forth day after transplantation were observed.Results The rate of positive cells in bone marrow and spleen:differences among four groups was not significant.The rate of positive cells of third day was highest among four days ( P <0.01).A phenomenon that homing-mobilization-rehoming could be observed.The homing efficiency:low dose groups were higher than that high dose groups ( P <0.01).Conclusion The homing efficiency of low dose groups is higher than that of the high dose groups in certain range,the routine method of transplanting a large quantities cells by a single injection may be an waste. |
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