| 李翊,王海青,周广清.扇贝提取物对荷瘤小鼠放射损伤的恢复作用[J].中华放射医学与防护杂志,2000,20(6):400-403.LI Yi,WANG Haiqing,ZHOU Guangqing.Effect of scallop extract on repair of radiation damage[J].Chin J Radiol Med Prot,2000,20(6):400-403 |
| 扇贝提取物对荷瘤小鼠放射损伤的恢复作用 |
| Effect of scallop extract on repair of radiation damage |
| 投稿时间：2000-01-20 |
| DOI： |
| 中文关键词: L615/放射治疗 扇贝提取物 放射损伤 恢复作用 |
| 英文关键词:L615/radiotherapy Scallop extract Radiation damage Repair effect |
| 基金项目:山东省科委基金资助项目(鲁科技9550) |
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| 中文摘要: |
| 目的 观察用192Ir核素照射联合扇贝提取物对荷瘤小鼠免疫和抗氧化功能的影响,了解扇贝提取物对放射损伤的恢复作用。方法 选用L615皮下荷瘤小鼠模型作照射,192Ir核素照射联合扇贝提取物组实验期间每天均以一定量的扇贝提取物灌胃,接种瘤株后第14天,开始192Ir核素照射,共3次,末次照射后的次日,进行免疫和抗氧化功能指标测定。结果 荷瘤鼠因192Ir核素照射而下降的免疫指标明显回升,包括脾脏NK细胞杀伤活性,丝裂原诱发的淋巴细胞转化强度,外周血白细胞总数及脾脏重量;并且,因照射而下降的抗氧化物酶谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性显着增高,脂质过氧化产物丙二醛(MDA)含量显着下降。结论 192Ir核素照射联合扇贝提取物可有效提高机体抗氧化能力,增强免疫活性,对放射损伤具有恢复作用。 |
| 英文摘要: |
| Objective To investigate the effects of combination of 192Ir-irradiation and scallop extract on antioxidative and immunological function in tumor-bearing mice and to understand the effect of the scallop extract on repair of radiation damage. Methods Tumor-bearing male L615 mice were subjected to 192Ir-irradiation.The mice of 192Ir-irradiation group were fed with scallop extract daily during the experiment. 192Ir-irradiation was started from fourteen days after cell inoculation.On the next day after the last 192Ir-irradiation, NK cell activity, the transformation strength induced by mitogens, spleen index, the glutathione peroxidase (GSH-Px)and superoxide dismutase (SOD) activities and the malondialdehyde(MDA)level were determined. Results The 192Ir-irradiation-caused decrease of immunological indicators increased markedly, including NK cell activity, the transformation strength induced by mitogens, spleen index.Moreover, 192Ir-irradiation caused decrease of GSH-Px and SOD activities and increase of MDA level in liver and blood all reversed significantly by scallop extract. Conclusion The combination of 192Ir-irradiation and scallop extract can enhance antioxidation ability and immunological function of tumor-bearing mice in radiotherapy and promote repair of radiation damage. |
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