| 高临路,崔玉芳,杨红,等.大剂量γ射线照射后小鼠脾脏淋巴细胞凋亡的病理形态学观察[J].中华放射医学与防护杂志,2000,20(5):327-329.GAO Linlu,CUI Yufang,YANG Hong,et al.Pathomorphology of spleen lymphocyte apoptosis in large dose 60Co γ-irradiated mice[J].Chin J Radiol Med Prot,2000,20(5):327-329 |
| 大剂量γ射线照射后小鼠脾脏淋巴细胞凋亡的病理形态学观察 |
| Pathomorphology of spleen lymphocyte apoptosis in large dose 60Co γ-irradiated mice |
| 投稿时间：1999-12-15 |
| DOI： |
| 中文关键词: 脾脏淋巴细胞 辐射 病理形态学 凋亡 |
| 英文关键词:Radiation Spleen lymphocyte Pathomorphology Apoptosis |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨大剂量60Coγ射线照射后脾脏淋巴细胞的病理形态学改变。方法 小鼠经6、9、12、15及2.0Gyγ射线照射, 于照后8个不同时间点活杀取材进行光镜及电镜观察。结果 照射后脾淋巴细胞凋亡的发生高峰与照射剂量和照后时间有关, 淋巴细胞数量显着减少。结论 照射后脾脏淋巴细胞凋亡的病理形态变化有明显的分期, 而在不同剂量组中细胞的死亡方式是有区别的。 |
| 英文摘要: |
| Objective The aim of this study was to investigate the pathomorphological changes of spleen lymphocyte apoptosis after 60 Co γ-irradiation. Methods The mice were irradiated with 6,9,12,15 and 20 Gy of 60 Co γ-rays. At different times after irradiation,the mice were sacrificed and the pathological changes of spleen lymphocyte were observed by light and transmission electron microscopies. Results Spleen lymphocyte decreased evidently and the peak of apoptosis in spleen lymphocyte was dependent on radiation dose and the time after irradiation. Conclusion After γ-irradiation with large doses,pathological changes of spleen lymphocyte apoptosis in mice can be divided into obviously different stages. The main causes of death of spleen lymphocytes are different in different dose groups. |
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