| 刘保国,张保民,陈肖华,等.内皮型一氧化氮合酶在急性放射性脑水肿中的表达[J].中华放射医学与防护杂志,2000,20(4):264-266.LIU Baoguo,ZHANG Baomin,CHEN Xiaohua,et al.Expression of endothelial nitric oxide synthase in acute radiation induced cerebral edema[J].Chin J Radiol Med Prot,2000,20(4):264-266 |
| 内皮型一氧化氮合酶在急性放射性脑水肿中的表达 |
| Expression of endothelial nitric oxide synthase in acute radiation induced cerebral edema |
| 投稿时间：1999-10-08 |
| DOI： |
| 中文关键词: 内皮型一氧化氮合酶 急性放射性脑水肿 60Coγ刀 |
| 英文关键词:Endothelial nitric oxide synthase Acute radiation induced cerebral edema 60Co gamma knife |
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| 中文摘要: |
| 目的 探讨大剂量60Coγ刀照射后脑血管内皮细胞内皮型一氧化氮合酶(eNOS)表达变化及其与急性放射性脑水肿的关系。方法 单次200Gy60Coγ刀照射大鼠右侧尾状核头部, 于照射后14d内分批活杀动物, 采用光镜、电镜、免疫组化及原位杂交技术研究照射后急性放射性脑水肿的发生发展及脑血管内皮细胞eNOS表达变化。结果 照射后2h出现急性放射性脑水肿病理改变, 照射后3d达高峰;脑血管内皮细胞eNOS于照射后2h亦出现明显表达增高, 且持续时间长, 伴行于放射性脑水肿急性发展阶段。结论 大剂量60Coγ刀照射后eNOS的表达增高可能与急性放射性脑水肿的发生发展有关。 |
| 英文摘要: |
| Objective To study the relation between changes in expression of endothelial nitric oxide synthase(eNOS)in brain vascular endothelial cells and acute radiation-induced cerebral edema after 60Co gamma knife irradiation with a high dose.Methods The right caudate nucleus of rats were irradiated with 200 Gy 60Co gamma knife. The rats were sacrificed within14 days after irradiation. By a light microscopy, electron microscopy, immunohistochemistry and in situ hybridization, we studied the formation and development of acute radiation induced cerebral edema as well as the expression of eNOSin brain vascular endothelial cells. Results Acute radiation induced cerebral edema was observed morphologically 2 hours after irradiation and peaked on day 3 after irradiation. The expression of eNOSin brain vascular endothelial cells markedly increased 2 hours after irradiation, which could be consistently visualized during the acute developmental phase of radiation induced cerebral edema.Conclusion The increased expression of eNOSmay be related to the formation and development of acute radiation induced cerebral edema after 60Co gamma knife irradiation with a high dose. |
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