中华放射医学与防护杂志

崔晓利,徐波,于振涛,等.高低氧放疗分次照射对小鼠肿瘤及正常组织的剂量效应[J].中华放射医学与防护杂志,2000,20(4):261-163.CUI Xiaoli,XU Bo,YU Zhentao,et al.Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy[J].Chin J Radiol Med Prot,2000,20(4):261-163

高低氧放疗分次照射对小鼠肿瘤及正常组织的剂量效应

Fractionated radiosensitization of murine tumor and normal tissue by carbogen plus low concentration oxygen radiotherapy

投稿时间：2000-01-30

DOI：

中文关键词: 高低氧放疗分次照射治疗增益

英文关键词:Carbogen plus low concentration oxygen radiotherapy Fractionated schedule Therapeutic gain factor

基金项目:

作者	单位
崔晓利	300060, 天津医科大学附属肿瘤医院
徐波	中国医学科学院中国协和医科大学肿瘤医院
于振涛	300060, 天津医科大学附属肿瘤医院
沈瑜	中国医学科学院中国协和医科大学肿瘤医院
王争	中国医学科学院中国协和医科大学肿瘤医院
殷蔚伯	中国医学科学院中国协和医科大学肿瘤医院

摘要点击次数: 3908

全文下载次数: 2773

中文摘要:

目的研究高低氧放疗分次照射对小鼠肿瘤及正常组织的剂量效应关系。方法实验肿瘤为T739小鼠LA795自发性肺腺癌, 以生长延缓为观察指标。正常组织以昆明鼠右后肢的皮肤反应作观察指标。实验分为单纯空气组、单纯高氧组、高低氧组。结果分次照射肿瘤放射增敏比(SER)高低氧组及高氧组分别为1.34、1.64, 皮肤反应SER高低氧组及高氧组分别为1.19、1.49, 高低氧组治疗获得系数(TGF)为1.13, 而单纯高氧组为1.10, 与单次照射相比均明显降低。结论对皮肤反应来说, 高低氧放疗分次照射明显降低单次照射带来的TGF.

英文摘要:

Objective To Study the dose response relationships of murine tumor and normal tissue in fractionated carbogen plus low concentration oxygen radiotherapy (CPLCOR).Methods The experiments included three groups: air, carbogen (95%O₂+5%CO₂), and carbogen plus low concentration oxygen (10%O₂+85%N₂+5%CO₂), five fractions were given to animals using a biological equivalence dose formula. The transplantable spontaneous tumor LA759 in inbred T739 mice was used for tumor response studies and the skin radiation reaction was evaluated with Douglas and Fowler grading method. Results In fractionated schedule, the sensitivity enhancement ratios (SER) were 1.34 and 1.64 for CPLCORand carbogen alone groups respectively. In skin response, the CPLCORgroup showed a relatively milder reaction than the carbogen group did: their SERwere 1.19 and 1.49 and the therapeutic gain factors (TGFs) for fractionated schedule were 1.13 and 1.10 respectively. Conclusions Compared with the results of single dose studies, TGFdecreases during fractionated irradiation, indicating that the CPLCORhas fewer advantage than carbogen radiotherapy.

HTML 查看全文查看/发表评论下载PDF阅读器

关闭