| 李秀娟,赫荣华,李修义,等.低剂量辐射适应性反应对辐射诱发小鼠胸腺淋巴瘤的影响[J].中华放射医学与防护杂志,2000,20(3):153-156.LI Xiujuan,HE Ronghua,LI Xinyi,et al.Influence of adaptative response to low dose radiation on radiation induced thymic lymphoma in mice[J].Chin J Radiol Med Prot,2000,20(3):153-156 |
| 低剂量辐射适应性反应对辐射诱发小鼠胸腺淋巴瘤的影响 |
| Influence of adaptative response to low dose radiation on radiation induced thymic lymphoma in mice |
| 投稿时间：1998-11-18 |
| DOI： |
| 中文关键词: 低剂量辐射 致癌剂量辐射 胸腺淋巴瘤 免疫功能 |
| 英文关键词:Low dose radiation Carcinogenic dose radiation Thymic lymphoma Immune functions |
| 基金项目:国家自然科学基金资助项目(39670190) |
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| 中文摘要: |
| 目的 探讨低剂量辐射对致癌剂量辐射诱发小鼠胸腺淋巴瘤的影响及其免疫学机理。方法 采用4次1.75GyX射线全身照射C57BL/6J小鼠诱发胸腺淋巴瘤模型, 观察不同剂量照后6个月小鼠胸腺淋巴瘤发生率, 照后1个月脾脏NK细胞毒活性、IL-2和γIFN分泌活性、腹腔巨噬细胞吞噬功能及其TNFα分泌活性以及胸腺细胞分化的变化。结果 每次1.75Gy照射前6h或12h接受25mGy或75mGy全身照射均可降低胸腺淋巴瘤发生率, 且预先接受75mGy全身照射的作用效果更为明显; 每次1.75Gy照射前12h接受75mGy照射小鼠, 上述免疫指标均比单纯1.75Gy照射组增强, 且多数指标接近假照射组; 其胸腺CD4-CD8-和CD4-CD8+细胞较单纯1.75Gy照射组减少、CD4+CD8+细胞增多。结论 低剂量辐射可诱导辐射诱发胸腺淋巴瘤适应性反应, 对致癌剂量辐射诱发小鼠胸腺淋巴瘤有抑制作用, 其抑制作用的免疫学机理可能与低剂量辐射的免疫增强效应及诱导的免疫学适应性反应, 减轻致癌剂量辐射对机体免疫功能的损伤, 使胸腺淋巴瘤前体细胞在形成胸腺淋巴瘤之前被免疫系统清除有关。 |
| 英文摘要: |
| Objective To search for influence of low dose radiation (LDR) on thymic lymphoma (TL) induced by carcinogenic dose radiation in C57BL/6J mice and its immunologic mechanism. Methods The model was adopted that C57BL/6J mice were subjected to whole body irradiation with 1.75 Gy Xray once every week for 4 weeks to induce TL.The incidence of TL was observed by microscopy 6 months after irradiation.The following indexes were examined:splenic NK cytotoxic activity, IL-2 and γ-IFN secretion activity.peritoneal macrophagic phagocytosis and its TNFα secretion activity the changes of thymocytedifferentiation in mice irradiated withdifferent dose 1 month after irradiation. Results The incidence ofTL in mice irradiated with 25mGy or 75mGy 6h or 12h before 1.75Gy irradiation were all lower than thatin mice irradiated with 1.75Gy only and it is more obvious in mice irradiated with 75mGy prior to car-cinogenic dose radiation. Immune parameters mentioned above in mice irradiated with 75mGy 12h before1.75Gy were higher than those in mice irradiated with 1.75 only and the majority approached to those of the sham-irradiated mice. The number of thymic CD4-CD8 cells or CD4-CD8-cells was lower andCD4+CD8+cells was higher in miceirradiatedwith 75mGy 12h before 1.75Gy than that in mice irradiat-ed with 1 .75Gy only. Conclusion LDR can induce the adaptative esponse of radiation-induced TL, andprevent or reduce the onset of radiation-induced TL.The suppression mechanism may be related to the im-munoenhancement effect and the adaptive response induced by LDR, decreasing immune function damage used by carcinogenic dose radiation eliminating thymic prelymphoma cells before they from solid tumor. |
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