| 汤喜成,胡椿枝,王慧君,曾爱萍.γ射线低剂量照射兔眼晶体损伤的实验观察[J].中华放射医学与防护杂志,2000,20(2):102-104 |
| γ射线低剂量照射兔眼晶体损伤的实验观察 |
| Experimental observation of lens damage after low doses of γ-ray irradiation to rabbit eyes |
| 投稿时间：1999-05-11 |
| DOI： |
| 中文关键词: γ射线 低剂量 晶体 TEM, SLM |
| 英文关键词:rays Low doses Lens Transmission electron microscope Slit lamp microscope |
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| 中文摘要: |
| 目的 探讨低剂量电离辐射对晶体的影响。方法 用25和50cGy<60Coγ射线一次照射兔眼后, 定期用透射电镜(TEM)和裂隙灯显微镜(SLM)观察晶体组织及形态学变化。结果 TEM观察到25和50cGy照射后早期均有明显晶体上皮细胞损伤, 表现为胞浆内粗面内质网、线粒体和高尔基氏器等膜性结构水肿及空泡变, 细胞间和胞浆内明显水肿, 大量空泡形成及层状小体增多。50cGy组更明显。SLM观察发现两剂量组照射后5个月, 其晶体后囊下均出现空泡状混浊, 50cGy组照射后11个月, 其晶体后囊下及深层皮质出现烟雾状混浊。结论本研究结果表明, 25及50cGy两低剂量照射后均有明显的晶体损伤。 |
| 英文摘要: |
| Objective To investigate and evaluate low dose γ-ray radiation induced lens damage. Methods Both eyes of each rabbit were exposed to a single dose of 25 or 50 cGy γ-rays in two groups,respectively. Samples were examined by transmission electron microscopy (TEM) and slit lamp microscopy (SLM)after irradiation. Results Three days after 25 and 50 cGy irradiation,the epithelial cells of lens equatoral region showed marked swelling and many vacuoles formed in intercellular space and cytoplasm,and accompanied by increased multilamellar bodies. Five months after irradiation,SLM of both groups showed that the posterior subcapsule cortex exhibited clusters of vaculoes; 11 months after 50 cGy irradiation,the posterior subcapsule and deep cortex manifested marked cloudy opacities. Conclusion Low doses of γ-ray (25 and 50 cGy) irradiation can markedly damage lens of rabbits. |
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