| 谷庆阳,王德文,高亚兵,崔彩彬,夏国伟,崔雪梅,熊呈琦.致伤前后不同时间照射对大鼠伤口愈合的影响规律[J].中华放射医学与防护杂志,2000,20(2):94-97 |
| 致伤前后不同时间照射对大鼠伤口愈合的影响规律 |
| Pathological study on regularity of wound healing in rats irradiated with γ-rays before or after suffering trauma |
| 投稿时间：1999-04-04 |
| DOI： |
| 中文关键词: 放射 伤口愈合 大鼠 胶原 |
| 英文关键词:Irradiation Wound healing Rats Collagen Comparative analysis |
| 基金项目:九五全军重点招标课题(96Z008) |
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| 中文摘要: |
| 目的 观察致伤前后不同时间照射对大鼠伤口愈合的影响规律。方法 采用大体及光镜观察、免疫组化(显示Ⅲ型胶原)和原位杂交(检测Ⅰ、Ⅲ型胶原mRNA)等方法, 动态观察致伤前后不同时间照射对大鼠伤口愈合影响的病理变化过程。结果 伤前2d至伤后7d照射均能延迟伤口愈合, 其中以伤后即刻照射影响最显着, 其余依次为伤后3d、伤前2d及伤后7d照射。结论 不同时间照射大鼠伤口愈合的影响程度不同。 |
| 英文摘要: |
| Objective To study the different effects of radiation on wound healing in rats irradiated with γ-rays before or after suffering trauma. Methods Animal models of wound healing were set up,and they were locally irradiated before or after suffering trauma.The pathological changes were studied by gross and microscopic examinations.Immunohistochemistry and in situ hybridization were performed to detect the expression of collagen types Ⅰ and Ⅲ. Results Wound healing was impaired and delayed obviously in rats locally irradiated with 15 Gy in the time period betwecn 2 days before and 7 days after receiving trauma.The strongest effect was observed in rats irradiated immediately after trauma.Irradiation given on day 3 after trauma and day 2 before trauma resulted in moderate effects,while the least effect was noted in rats irradiated on day 7 after trauma. Conclusion The effect of radiation on wound healing depends on the time of irradiation before or after receiving trauma. |
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