| 胡璧,沈瑜,周则卫,王争,张荷清.CGEONA对荷LA-795肺腺癌小鼠和正常小鼠放射敏感性的影响[J].中华放射医学与防护杂志,2000,20(2):77-79 |
| CGEONA对荷LA-795肺腺癌小鼠和正常小鼠放射敏感性的影响 |
| Effect of CGEONA on radiosensitivity in LA-795 pulmonary adenocarcinoma-bearing mice and normal mice |
| 投稿时间：1999-07-08 |
| DOI： |
| 中文关键词: 锗倍半氧化物 放射增敏剂 肿瘤再生长延缓 增敏比 放射防护作用 |
| 英文关键词:Germanium sesquioxide Radiosensitizer Tumor regrowth delay Sensitization enhencement ratio Radioprotection |
| 基金项目:国家自然科学基金(39370226) |
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| 中文摘要: |
| 目的 为了寻找低毒有效的放射增敏剂, 观察CGEONA(羧基苯乙烯基锗倍半氧化物钠盐)对荷瘤小鼠和正常小鼠放射敏感性的影响。方法 放射增敏实验用T-739小鼠, 肿瘤模型LA-795肺腺癌, 采用肿瘤再生长延缓法评价效果;放射防护实验用昆明种小鼠, 观察30d存活率和对造血系统的影响。结果 CGEONA药物浓度为1/10 LD50时平均放射增敏比为1.4.放射防护实验给药组与对照组相比, 存活率以及造血系统指标无明显差异。结论 CGEONA是新型低毒有效放射增敏剂, 对照射的正常动物无放射增敏作用, 值得进一步研究。 |
| 英文摘要: |
| Objective In search for less toxic and more effective radiosensitizer.The effects of CGEONA (carboxy-β -phenyl-vinyl-germanium sesquioxide sodium salt) on radiosensitivity in tumor-bearing mice and normal mice were investigated. Methods Radiosensitization experiments were performed on T-739 mice.tumor model was LA-795 pulmonary adenocarcinoma and tumor response was assessed using a regtowth delay.Radioprotection experiments were performed on Kunming mice. The 30-day survival rate and effect on hemopoietic system were observed. Results The average sensitization enhancement ratio of CGEONA was 1.4 using 1/10 LD 50 drug dose.The radioprotection experiments showed no significant difference between treated mice and control mice for survival rate and hemopoietic systcm. Conclusion CGEONA shows great potential as a new type radiosensitizer with less toxicity and more effectiveness. It has no radiosensitizing effect on normal mice and is worthy of further studies. |
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