| 刘伟,侯殿俊,乔建维,商希梅,李洁清.低剂量辐射对LAK/TIL培养扩增及抗肿瘤作用的实验研究[J].中华放射医学与防护杂志,2000,20(1):40-42 |
| 低剂量辐射对LAK/TIL培养扩增及抗肿瘤作用的实验研究 |
| Influence of low dose ionizing radiation on amplification and antitumor activity of LAK/TIL cells |
| 投稿时间：1999-02-08 |
| DOI： |
| 中文关键词: 低剂量 电离辐射 LAK/TIL细胞 扩增 细胞毒性 |
| 英文关键词:Low dose Ionizing radiation LAK/TIL cells Amplification Cytotoxicity |
| 基金项目:山东省科委基金资助项目[(94)197] |
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| 中文摘要: |
| 目的 为了解低剂量电离辐射对LAK/TIL细胞培养扩增及抗肿瘤作用的影响。方法 从荷瘤小鼠的脾脏制得LAK细胞, 从荷Lewis肺癌小鼠瘤组织中分离得TIL细胞, 给予不同剂量的X射线照射后培养。结果 低剂量电离辐射可增加LAK/TIL细胞的扩增量, 降低细胞扩增过程死亡率, 并增加细胞毒性。结论 低剂量电离辐射对生物活性细胞不仅有诱导扩增作用, 同时亦降低扩增过程细胞死亡率。 |
| 英文摘要: |
| Objective To study the influence of low dose ionization on amplification and antitumor activity of LAK/TIL cells. Methods TIL cells isolated from Lewis lung cancer tissues and LAK cells from spleen of tumor bearing mouse were irradiated with different low doses of X rays and were cultured after irradiation. Results Low dose ionizing radiation improved the amplification volume of LAK/TIL cells,decreased the cell death ratio in amplification process,and increased the toxicity of LAK/TIL cells. Conclusions Low dose ionizing radiation can result in amplification of biologically activated lymphocytes,and decreases the death ratio of the cells in amplification process. |
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