| 袁雄,叶常青,路秀琴,张灿哲.重离子照射致人气管上皮细胞突变效应[J].中华放射医学与防护杂志,1999,19(5):300-302 |
| 重离子照射致人气管上皮细胞突变效应 |
| Mutation of human bronchial epithelial cells induced by heavy ions |
| 投稿时间：1998-10-08 修订日期：1999-04-11 |
| DOI： |
| 中文关键词: hprt 突变 重离子 LET 突变截面 |
| 英文关键词:hprt Mutation Heavy ions LET Cross section mutation |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 探讨重离子诱发人支气管上皮细胞系的突变效应。方法 用HI-13串列加速器产生的Li、C、F三种离子束以0.5～6.0Gy设计剂量照射人支气管上皮细胞系突变,观察其突变效应。结果 细胞hprt突变率(MF,无量纲)与重离子剂量(D,Gy)的线性回归方程分别为MF=1.63×10-5D(Li)、MF=8.64×10-5D(C)、MF=1.33×10-5D(F);与60Coγ射线比较,其相对生物效应依次为1.27、6.78、1.04.此突变率与粒子注量亦呈线性正相关,三种重离子的突变截面(σm,10-4μm2)依次为2.61、41.5、21.3.致突性(σm/σi,10-5)依次为2.08、10.2、2.78.结论 细胞突变率随重离子剂量增大而上升,似有LET依赖性。 |
| 英文摘要: |
| Objective To observe the mutation characteristic of human bronchial epithelial cell line induced by heavy ions. Methods The human bronchial epithelium cell line(BEAS-2B)was irradiated by heavy particle beams of Li, C, and F from an HI-13 tandem accelerator with the designed dose ranging from 0.5Gy～6.0 Gy, and their hprt mutation was analyzed. Results The fitted dose dependent linear equations for three categories of heavy ions were MF=1.63×10-5 D(Li), MF=8.64×10-5 D(C)and MF=1.33×10-5 D(F) respectivelyhere the dimension of dose is Gy.The RBEs were 1.27, 6.78, and 1.04 for Li, C and F, respectively, compared with γ ray irradiation.All the frequencies of hprt mutant have also shown positive linearity with fluence. Finally, the cross sections of mutation (σ-m, 10-4 μm2) and the mutagenicity(σ m/σ i, 10-5 )for Li, C and F, were 2.61, 41.5, 21.3 and 2.08, 10.2, 2.78 respectively. Conclusion The frequencies of cell mutation increase with the dose and there seems to be LET dependence. |
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