| 周湘艳,王冰,高卫民,等.氚水照射对发育中的中枢神经系统影响——低水平氚剂量阈值研究[J].中华放射医学与防护杂志,1999,19(4):254-257.ZHOU Xiangyan,WANG Bing,GAO Weimin,et al.Threshold dose to developing central nerve system of rats and mice from prenatal exposure to tritiated water[J].Chin J Radiol Med Prot,1999,19(4):254-257 |
| 氚水照射对发育中的中枢神经系统影响——低水平氚剂量阈值研究 |
| Threshold dose to developing central nerve system of rats and mice from prenatal exposure to tritiated water |
| 投稿时间：1999-03-22 修订日期：1999-05-04 |
| DOI： |
| 中文关键词: 氚水 大鼠 小鼠 中枢神经系统 海马 Ca2＋电流 阈值 |
| 英文关键词:Tritiated water Rats Mice Central nerve system Hippocampus Ca2+ conductance Threshold dose |
| 基金项目:国家自然科学基金;卫生部医学研究基金 |
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| 中文摘要: |
| 目的 研究大、小鼠出生前受氚水照射对发育中的中枢神经系统影响的剂量阈值。方法 选用孕龄12.5天和13.0天的C57BL/6J小鼠和Wistar大鼠,每克体重注入氚水活度(×104Bq)分别为0.00、24.09、48.18和144.54, 观察仔代生长发育、神经行为、脑细胞学、脑神经肽含量、海马神经元和Ca2+电流幅度改变等56项生物学指标与对照组比较出现显着差异的最低剂量。结果 以大鼠和小鼠为实验对象,观察的56项生物学指标中,氚的致畸阈值：80.4%的指标分布在0.030～0.092Gy范围内,有少数指标(19.6%)分布在0.093～0.300Gy范围内。结论 通过上述研究结果证明低水平氚照射对发育中的中枢神经系统影响存在剂量阈值。 |
| 英文摘要: |
| Objective sTo study the threshold dose to the developing central nerve system of rats and mice from prenatal exposure to tritiated water. Methods Pregnant adult C57BL/6J strain mice and Wistar strain rats were irradiated with betarays from HTO by a single intraperitoneal injection on the 12.5th and 13th days of gestation.The activities of HTO were 24.09, 48.18 and 144.54 (104Bq/g bw), respectively.Fiftysix parameters including postnatal growth, neurobehavior, pathology of brain, neuropeptide contents, changes of hippocampal neurons, Ca2+ conductance of hippocampal neurons etc were used to test the teratogenic threshold dose (the lowest dose was different from that of the control). Results Of the observed 56 parameters of rats and mice 804% indicated that the threshold doses for prenatal HTO exposure ranged from 0.030 Gy to 0.092 Gy, and the other 19.6% showed the threshold doses from 0.093 to 0.300 Gy. Conclusions There exists threshold dose from the low level tritiated water irradiation of the developing central nerve system |
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