| 王迎选,汪力,乔广宇,周定标.不同剂量照射后猪下丘脑血清激素及靶腺器官反应观察[J].中华放射医学与防护杂志,1999,19(4):248-250 |
| 不同剂量照射后猪下丘脑血清激素及靶腺器官反应观察 |
| Serum hormone and target organ responses after irradiation of hypothalamus with various doses |
| 投稿时间：1999-01-25 修订日期：1999-03-10 |
| DOI： |
| 中文关键词: 放射反应 下丘脑 血清激素 |
| 英文关键词:Radiation response Hypothalamus Serum hormone |
| 基金项目:全军“九五”课题基金 |
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| 中文摘要: |
| 目的 结合当前临床开展的立体定向放射外科(SRS)和立体定向放射治疗(SRT)技术,对下丘脑神经内分泌功能的放射耐受剂量作初步探讨,为临床SRS、SRT治疗提供基础研究。方法 对幼年猪下丘脑予以单次不同剂量照射,进行下丘脑及其靶腺器官的组织学观察,观察照射后血清睾酮、T3、T4、皮质醇水平的动态变化。结果 下丘脑区5～20Gy单次照射后,血清睾酮水平的降低出现得最早,15Gy及20Gy组血清睾酮水平在照射后呈持续低水平,此二组动物在照射后4～8周曾出现一过性甲状腺素水平降低,但其甲状腺功能基本正常,血清皮质醇水平未出现改变。结论 ①下丘脑神经分泌细胞具有不同的放射敏感性,可能以GnRH神经细胞最为敏感。②下丘脑TRH神经细胞对5～20Gy单次照射有一定的耐受性。③下丘脑促肾上腺皮质激素释放因子神经细胞分泌功能对5～20Gy单次剂量照射可以耐受。 |
| 英文摘要: |
| Objective To detect radiation response of neuroendocrine function after single dose irradiation to hypothalamus and to provide a fundamental study for SRS and SRT. Methods Porcine hypothalamus regions were irradiated by 5, 10, 15 and 20 Gy with 10 MV X-rays.The serum levels of testosterone, T3, T4 and cortisol were measured.At the 40th week, hypothalamus, testes, thyroids and adrenals were obtained for histopathological examination. Results Significant gliosis in hypothalamus region irradiated with 15 and 20 Gy was observed by electron microscopy.The serum testosterone levels declined in all irradiated groups but it was recovered to normal afterward in 5 Gy group.Remarkable atrophy in testis insterstitia was noticed in 15 Gy and 20 Gy groups at the 40th week after irradiation.No significant changes in T3 and T4 levels were found, but the degeneration of the thyroids was observed in 15 Gy and 20 Gy groups. Conclusions Hypothalamus is vulnerable to radiation, 5 Gy single dose irradiation is well tolerated and single dose above 10 Gy may cause significant deficiency in the GnRH secretion.TRH cells of hypothalamus may maintain normal function after 5-20 Gy single dose irradiation. |
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