| 姜涛,早田勇,王春燕,等.高本底辐射诱发居民外周血淋巴细胞染色体畸变的剂量效应关系[J].中华放射医学与防护杂志,1999,19(2):104-107.JIANG Tao,HAYATA I,WANG Cunyan,et al.Dose effect relationship in production of dicentrics and rings in blood lymphocytes of individuals living in high background radiation area[J].Chin J Radiol Med Prot,1999,19(2):104-107 |
| 高本底辐射诱发居民外周血淋巴细胞染色体畸变的剂量效应关系 |
| Dose effect relationship in production of dicentrics and rings in blood lymphocytes of individuals living in high background radiation area |
| 投稿时间：1998-07-10 修订日期：1998-10-10 |
| DOI： |
| 中文关键词: 高本底辐射 染色体畸变 剂量效应关系 |
| 英文关键词:High background radiation Chromosome aberrations Dose effect relationship |
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| 全文下载次数: 2005 |
| 中文摘要: |
| 目的 通过人群调查探讨高本底辐射诱发居民染色体畸变的剂量 效应关系,为建立环境小剂量辐射剂量 效应模型和评估群体剂量提供参考。方法 39名调查对象选自高本底和对照地区13个家庭中的祖、父、子三代成员。个体累积剂量分别为23.9～261.3和52～29.8mGy.分离淋巴细胞培养法制备染色体标本,总计观察细胞数约100000.结果 ①在高本底组每一家庭中均观察到个体染色体畸变率随年龄增加而升高,其趋势在户间差异无显着性。②高本底组不同年龄个体染色体畸变率与年龄和累积剂量密切相关,可拟合为线性一次式：Yage=0.0448X+0.4913(R2=0.7814);Ydose=0.0156X+0.5715(R2=0.7061);③对照组个体间畸变率差异不显着,其平均畸变率接近正常人群自发畸变率。结论 高本底持续照射诱发的人体内双着丝点加环畸变随受照时间的延长而持续升高。双加环畸变分析可作为小剂量持续照射的可信赖的生物剂量仪,但存在一个应用上的累积剂量阈值,其值约为50mGy. |
| 英文摘要: |
| Objective To explore the dose effect relationship in the production of chromosome aberrations by high background radiation by using statistically appropriate individual measurements. Methods Chromosome analysis was performed in separated blood lymphocytes of 39 family memders of different ages from either high background radiation area(HBRA) or control area (CA).Individual cumulative doses ranged from 23.9-261.3 and 5.2-29.8 mGy for HBRA and CA,respectively.A total of about 100,000 cells were scored and dicentric and ring chromosome (dic+Rc)aberrations recorded.Results In the case of HBRA,individual chromosome aberration frequencies increased with age within each family.The increasing trend was in general not significantly different among families.The increase in individual aberration was closely correlated with age and cumulative dose.Age-and dose effect relationship fit well the linear equation:Y=0.0448X+0.4913(R2=0.7814)for age and Y=0.0156X+0.5715(R2=0.7061)for cumulative dose,respectively.In the case of CA,there was no significant difference in aberration yields among individuals of different ages,and the group mean aberration frequency was 1.24±0.69×10-3 . Conclusiones Dic and Rc can continuously accumulate over a liftime chronic low dose exposures,and can serve as a reliable biological indicattor.However,the ultimate sensitivity is about 50 mGy. |
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