| 孙全富,邹剑明,秋叶澄伯,等.阳江高本底地区群组研究1979～1995年随访数据合并与统计分析方法[J].中华放射医学与防护杂志,1999,19(2):95-98.SUN Quanfu,ZOU Jianming,AKIBA S,et al.Data pooling and statistical analyses of cohort studies (1979-1995) in Yangjiang, China[J].Chin J Radiol Med Prot,1999,19(2):95-98 |
| 阳江高本底地区群组研究1979～1995年随访数据合并与统计分析方法 |
| Data pooling and statistical analyses of cohort studies (1979-1995) in Yangjiang, China |
| 投稿时间：1998-10-08 修订日期：1998-11-15 |
| DOI： |
| 中文关键词: 群组研究 数据库 记录连接 危险分析 |
| 英文关键词:Cohort study Database Record linkage Risk analysis |
| 基金项目: |
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| 摘要点击次数: 3261 |
| 全文下载次数: 1995 |
| 中文摘要: |
| 目的 讨论阳江高本底地区群组研究不同阶段的资料合并与癌症危险的统计分析。方法 调查分阶段进行,1970～1978年为回顾性调查,1979～1986年为动态人群前瞻性观察,1987～1995年为定群研究,后两个阶段的数据已经计算机化。采用记录连接方法进行1979～1986年和1987～1995年随访数据的合并。危险分析基于详细的人年列表,分组变量包括性别、到达年龄(at-tendedage)、随访年份和剂量分组。利用标准的Poisson回归方法估计超额相对危险和与对照组相比高本底地区每个剂量组的相对危险。采用似然比χ2近似方法计算显着性检验的双侧P值和95%置信区间。结果 由于某些成员的出生日期在两个随访阶段数据库中有所不同及其他原因,约有10%的群组成员未能完成记录连接。我们讨论了合并随访数据的三种方法。结论 癌症危险分析基于1979～1995年记录连接合并资料,包括125079人,累计观察1698350人年,10415人死亡,其中1003人为癌症死亡。癌症危险估计的结果将有另文专门讨论。 |
| 英文摘要: |
| Objective Cohort studies on cancer mortality among inhabitants in the high background radiation area (HBRA) of Yangjiang,China,was started in 1972.The purpose of the investigation was to explore cancer risks associated with chronic exposure to low dose ionizing radiation.In this paper,we describe data pooling and methods of cancer risk estimation used in Yangjiang HBRA study. Methods HBRA epidemionogical surveys were carried out in consecutive periods,i.e.,retrospective survey (1970-1978),dynamic population follow up (1979-1986),and fixed cohort study (1987-1995).The surveys included tracing and folow up of cohort members,ascertainment of causes of death,and measurements of indoor/outdoor gamma exposure and individual cumulative doses.Record linkage was used to combine the follow up data of the dynamic population (1979-1986) and the fixed cohort (1987-1995).Risk analysis was based on detailed tabulation of person years stratified by sex,age at risk,follow up interval,and dose group.The basic data for each cell in these tables included the numbers of cancer deaths,other deaths interested,and person years.These data were supplemented by cell-specific person year weighted means of cumulative doses and age at risk.The person year tabulations were prepared using DATAB in Epicure.Standard Poisson regression method was used to estimate excess relative risk per sievert,and relative risks for each dose groups in HBRA compared with control group.Significance test (two-sided P value) and 95% confidence intervals were calculated by χ 2 approximation to likelihood ratio method.Risks were estimated using AMFIT in Epicure. Results Due to differences in date of birth of some subjects and other reasons,about ten percent of subjects failed to link.Conclusione Cancer risk analysis was based on the pooled data for the period 1979 1995,which included 125079 subjects,accumulated 1698350 person-years,and observed 1003 cancer cases among 10415 deaths.Cancer risks are discussed in another paper. |
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