| 刘林林,刘建香,鞠桂芝.X射线照射对人外周血淋巴细胞mIL-2R表达的影响[J].中华放射医学与防护杂志,1999,19(1):24-26 |
| X射线照射对人外周血淋巴细胞mIL-2R表达的影响 |
| Effect of X rays on mIL-2R expression of human lymphocytes |
| 投稿时间：1998-09-15 修订日期：1998-12-11 |
| DOI： |
| 中文关键词: 电离辐射 mIL-2R 适应性反应 |
| 英文关键词:Ionizing radiation mIL-2R Adaptive response |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 观察X射线照射对人外周血淋巴细胞mIL-2R表达的影响。方法 采用单克隆抗体间接免疫荧光标记FCM检测。结果 4Gy和6Gy单次照射组mIL-2R表达明显低于对照组(分别P<0.01).75mGy及100mGy单次照射组mIL2R表达明显高于对照组(分别P<0.01).预先给予75mGy照射, 继之又给予4Gy组mIL-2R表达明显高于单纯4Gy照射组。结论 ①4Gy以上X射线照射使mIL-2R的表达明显降低。②75mGy及100mGy小剂量照射后人外周血淋巴细胞mIL-2R表达显着增高。③75mGy预照射可诱导mIL-2R表达对其后4Gy照射的适应性反应。 |
| 英文摘要: |
| Objective The mIL-2R expression of human peripheral blood lymphocytes after X irradiation with different doses was investigated.Method Indirect fluorescence analysis with flow cytometry was used. Results After 4 Gy or 6 Gy irradiation,the expression of mIL-2R was significantly lower than that of control (both P <0.01).However,the mIL-2R expression of lymphocytes was significantly higher than that of the control after irradiation with 75 mGy or 100 mGy ( P <0.001 and P <0.01,respectively).Furthermore, it was demonstrated that the mIL-2R expression in the group preirradiated with 75 mGy was higher than that in group irradiated with 4 Gy only. Conclusion 4 Gy or 6 Gy X-irradiation reduced the mIL-2R expession of human peripheral blood lymphocytes,while mIL-2R expression was increased after irradiation with 75 mGy or 100 mGy;75 mGy preirradiation could induce adaptive response of mIL-2R expression. |
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