| 刘青杰,陈德清.低剂量γ射线对小鼠产生血清特异性抗体的影响[J].中华放射医学与防护杂志,1998,18(6):403-405 |
| 低剂量γ射线对小鼠产生血清特异性抗体的影响 |
| Hormesis of specific IgG antibody to rabies virus in serum of mice irradiated with low dose γ-rays. |
| 投稿时间：1998-05-07 修订日期：1998-12-03 |
| DOI： |
| 中文关键词: 免疫刺激 低剂量辐射 小鼠 狂犬病毒 特异性IgG |
| 英文关键词:Humoral immune hormesis Low dose γ-rays Mice Rabies virus Specific IgG |
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| 中文摘要: |
| 目的 探讨低剂量电离辐射对小鼠特异性抗体产生是否有影响。方法 昆明种雄性小鼠单次照射60Coγ射线后,用狂犬疫苗全程免疫,ELISA法测定小鼠狂犬病毒特异性IgG抗体水平。结果 ①5～30cGyγ射线照射的小鼠血清中特异性抗体水平显着高于对照,其中10cGy为刺激血清特异性抗体产生的最佳剂量;②10cGy照射,小鼠血清中特异性抗体水平的峰值显着高于对照组的峰值,而且其峰值提前出现;③10cGy照射引起的特异性抗体水平的增高可持续1周。结论 低剂量电离辐射可对小鼠血清特异性抗体的产生有刺激作用,并可持续一定的时间。 |
| 英文摘要: |
| Objective To explore the effect of low dose ionizing radiation on specific antibody in mouse serum.Methods Kunming strain male mice, weighing 18-22 g, aged 6-8 weeks, were immunized intraperitoneally with rabies vaccine after exposure to cobalt 60 γ-rays.The specific IgG antibody against rabies virus in mouse serum was measured.Results (1)The serum levels of specific IgG in mice irradiated with 5-30 cGy γ-rays were significantly elevated in comparison with those in control mice (P<0.01), the optimum stimulating dose being 10 cGy.(2)Exposure to 10 cGy caused significant enhancement and earlier emergence of the peak level of specific IgG in serum.(3)The hormesis of specific IgG to rabies virus induced by 10 cGy γ-rays could last one week at least.Conclusion Low dose ionizing radiation can enhance the level of specific antibody in mouse serum, and this effect can last for one week at least. |
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