| 邹仲敏,孙慧勤,罗成基.6Gyγ射线照射诱导骨髓造血细胞凋亡[J].中华放射医学与防护杂志,1998,18(6):390-392 |
| 6Gyγ射线照射诱导骨髓造血细胞凋亡 |
| 6Gyγ-irradiation induces apoptosis of bone marrow hematopoietic cells. Zou Zhongmin,Sun Huiqin,Luo Chengji. Department of Radiatio |
| 投稿时间：1997-12-25 修订日期：1998-03-18 |
| DOI： |
| 中文关键词: 造血细胞 细胞凋亡 辐照 |
| 英文关键词:Hematopoietic cells Apoptosis Irradiation |
| 基金项目: |
|
| 摘要点击次数: 2718 |
| 全文下载次数: 1721 |
| 中文摘要: |
| 目的 研究凋亡在射线损伤造血功能中的作用。方法 用原位末端标记(ISEL)、电镜技术和流式细胞术,研究6Gyγ射线照射后小鼠骨髓造血细胞(BMHCs)的凋亡。结果 在体射线损伤后,除细胞坏死外,骨髓造血细胞的形态学变化还与凋亡的特点相符。时效关系的研究显示射线照射后8小时BMHC凋亡发生率达最高水平(约30%),之后有所下降。结论 射线损伤造血功能的主要途径之一是诱导细胞发生凋亡。 |
| 英文摘要: |
| Objective To study the role of apoptosis in radiation induced dysfunction of hematopoiesis.Methods Apoptosis of bone marrow hematopoietic cells (BMHCs) in 6Gy γ irradiated mice was detected by in situ end labelling (ISEL), electron microscopy and flow cytometry.Results Except necrosis, the morphological characteristics of BMHCs after irradiation were consistent with those of apoptosis.The study on time effect relationship showed that the percentage of apoptotic cells in BMHCs reached its peak (about 30%)8h after irradiation and then declined. Conclusion Apoptosis is one of important ways of death of irradiated hematopoietic cells. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|