| 徐辉,程天民,粟永萍,阎国和,林远,古德全.8Gy全身辐射对小鼠小肠上皮内淋巴细胞数量及功能的影响[J].中华放射医学与防护杂志,1998,18(6):373-376 |
| 8Gy全身辐射对小鼠小肠上皮内淋巴细胞数量及功能的影响 |
| Effects of 8Gy whole body irradiation on number and functions of small intestinal intraepithelial lymphocytes(IELs). |
| 投稿时间：1998-02-25 修订日期：1998-04-27 |
| DOI： |
| 中文关键词: 辐射 上皮内淋巴细胞 细胞增殖 细胞毒 |
| 英文关键词:Radiation Intraepithelial lymphocytes Cell proliferation Cytotoxine |
| 基金项目:全军“九五”指令性攻关课题资助 |
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| 中文摘要: |
| 目的 探讨辐射损伤对粘膜免疫的影响。方法 小鼠全身照射8Gy后,分离培养小肠上皮内淋巴细胞,并对其数量、细胞增殖活力、细胞毒力、TNF-α和TGF-β分泌水平进行检测。结果 小肠上皮内淋巴细胞数量明显下降,增殖活力和细胞毒力明显受抑,都表现为伤后8小时下降,72小时达最低值。上皮内淋巴细胞分泌TNF-α和TGF-β显着增多,表现为伤后8小时增高,72小时达峰值。结论 小肠上皮内淋巴细胞数量减少和功能降低成为全身放射损伤时造成肠粘膜免疫屏障功能受损的一个重要原因。 |
| 英文摘要: |
| Objective To explore the characteristics of intestinal mucosal immunity after radiation injury. Methods Number, proliferation activity, cytotoxicity of IEL as well as the TNF-α and TGF-β concentrations in supernatant of cultured IELs were studied using freshly isolated IELs from whole small intestine of Kunming strain mice whole body irradiated with 8Gy 60Co rays.Results The proliferation activity, cytotoxicity as well as the number of IELs in small intestinal mucosa were significantly decreased from 8h and reached the lowest level at 72h post irradiation. The TNF-α and TGF-β concentrations in supernatant of cultured IELs isolated from irradiated mice elevated at 8h and reached the peak values at 72h.Conclusion The decrease in number and important functions of IELs might be one of the reasons which damage the intestinal mucosal immunity barrier after whole body irradiation. |
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