| 曹珍山,樊飞跃,涂开成,等.131I和132I致大鼠甲状腺滤泡上皮细胞核的形态计量学改变[J].中华放射医学与防护杂志,1998,18(4):266-269.,et al.Morphometric changes in epithelial cell nuclei of rat thyroid follicles induced by 131I and 132I[J].Chin J Radiol Med Prot,1998,18(4):266-269 |
| 131I和132I致大鼠甲状腺滤泡上皮细胞核的形态计量学改变 |
| Morphometric changes in epithelial cell nuclei of rat thyroid follicles induced by 131I and 132I |
| 投稿时间：1997-12-03 修订日期：1998-02-27 |
| DOI： |
| 中文关键词: 形态计量学 131I 132I 甲状腺 细胞核 |
| 英文关键词: |
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| 中文摘要: |
| 目的 为放射性碘危害与医学防护的研究提供资料。方法 应用图像分析技术和形态计量学方法, 测量了131I、132I注入后20个月大鼠甲状腺滤泡上皮细胞核的形态计量学参数的变化。结果 各剂量组滤泡上皮细胞核截面积、等效直径增大, 形状因子明显小于对照组(P<0.05或P<0.01), 异形指数明显大于对照组(P<0.05～P<0.01), 体积密度, 表面积密度、数密度呈先增加后减少的变化特点。结论 表明细胞受到放射性碘照射后胞核增大, 其形状不仅扁而且异形；体积密度、表面积密度增加或减小的原因是由于胞核数密度的改变所致；对细胞核数密度与放射性碘致甲状腺肿瘤发生率的回归分析发现, 两者呈明显的正相关关系, 表明肿瘤发生率的高低与单位体积上细胞的数量有关。 |
| 英文摘要: |
| Objective To study harmfulness of radioiodine and its medical protection.Method By using image analysis technique and morphometry, changes in morphometric parameters in epithelial cell nuclei of rat thyroid follicles were determined 20 months after injection of 131I and 132I.Results The results showed that in various dosage groups the area and eqivalent diameter enlarged, the morphometric factor was evidently smaller than that of the control group(P<0.05 or P<0.01), and the form irregular index was significantly larger than that of the control group (P<0.05 P<0.01).The volume density, surface area density, numerical density of nuclei of follicular epithelial cells in various dose groups all showed the feature of increase at first and reduction afterwards.Conclusion It is indicated that the nuclei of epithelial cells increased and its shape became not only flat, but also anisomorphic after the cells were irradiated with radioiodine.The reason why volume density and surface area density showed increase or decrease is due to the change in numerical density of nuclei of epithelial cells.It was found by regresion analysis of the numerical density of nuclei of epithelial cells and incidence of thyroid tumor induced by radioiodine that they bear a remarkable positive correlation[Y=1/(3.37×103 +5.85×103/X1), R1=0.8435], suggesting that the incidence of thyroid tumor is related to the number of cell per unit volume. |
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