| 王知权,孙元明,李进,等.用荧光原位杂交快速检测医用诊断X射线工作者染色体结构重排及其剂量估算的探讨[J].中华放射医学与防护杂志,1998,18(4):263-265.Wang Zhiquan,Sun Yuanming,Li Jin,et al.Rapid detection of chromosome rearrangement in medical diagnostic X-ray workers by using fluorescence in situ hybridization and study on dose estimation[J].Chin J Radiol Med Prot,1998,18(4):263-265 |
| 用荧光原位杂交快速检测医用诊断X射线工作者染色体结构重排及其剂量估算的探讨 |
| Rapid detection of chromosome rearrangement in medical diagnostic X-ray workers by using fluorescence in situ hybridization and study on dose estimation |
| 投稿时间：1997-10-31 修订日期：1997-12-22 |
| DOI： |
| 中文关键词: 荧光原位杂交 医用诊断X射线工作者 生物剂量 |
| 英文关键词:Fluorescence in situ hybridization Medical diagnostic X-ray workers Biological dose |
| 基金项目:日中医学会和中国医学科学院中国协和医科大学院校基金 |
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| 中文摘要: |
| 目的 对早年从事医用诊断X射线工作者作生物剂量估算。方法 用4和7号全染色体探针的荧光原位杂交分析染色体的结构性重排。结果 医用诊断X射线组与对照组相比易位率明显增高, 用易位率可以推算出医用诊断X射线工作者的生物剂量, 与用G带方法所得易位率基本一致。结论 首次用荧光原位杂交技术, 对没有或基本没有剂量记载的医用诊断X射线工作者的生物剂量作了估算 |
| 英文摘要: |
| Objective Biological doses were estimated for medical diagnostic X-ray workers.Methods Chromosome rearrangements in X-ray workers were analysed by fluorescence in situ hybridization (FISH) with composite whole chromosome paintings 4# and 7#.Results The frequency of translocation in medical diagnostic X-ray workers was much higher than that in control group (P<0.01).The biological doses to individual X-ray workers were calculated by their translocation frequency.The translocation frequencies of both FISH and G banding were in good agreement.Conclusion The biological doses to X-ray workers are estimated by FISH first when their dosimetry records are not documented. |
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