| 刘文励,孙汉英,周剑锋,等.复方活血汤对放射性损伤小鼠造血细胞bcl-2、bax、bcl-xL基因表达的作用[J].中华放射医学与防护杂志,1998,18(4):256-258.Liu Wenli,Sun Hanying,Zhou Jianfeng,et al.Effect of compound blood activating decoction on expression of bcl-2, bax and bcl-xL genes in bone marrow hematopoietic cells of radiation injured mice[J].Chin J Radiol Med Prot,1998,18(4):256-258 |
| 复方活血汤对放射性损伤小鼠造血细胞bcl-2、bax、bcl-xL基因表达的作用 |
| Effect of compound blood activating decoction on expression of bcl-2, bax and bcl-xL genes in bone marrow hematopoietic cells of radiation injured mice |
| 投稿时间：1997-04-21 修订日期：1997-08-12 |
| DOI： |
| 中文关键词: 放射损伤 造血细胞 bcl-2基因 bax基因 bcl-xL基因 |
| 英文关键词:Radiation injury Hematopoietic cells bcl-2 gene bax gene bcl-xL gene |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 探讨放射性损伤骨髓衰竭的机理及防护对策。方法 用Northernblot技术检测了60Co γ射线8.0Gy照射小鼠(对照组)及照射后立即给复方活血汤治疗小鼠(中药组)的骨髓有核细胞bcl-2、bax、bcl-xL基因表达。结果 放射损伤后第3, 7天, 对照组骨髓有核细胞bcl-2/bax值减小、bcl-xL不表达。中药组与之相反, bcl-2/bax值明显增大、bcl-xL明显表达。受照后第7天两组脾脏单个核细胞bcl-2/bax值与骨髓有核细胞的表达一致。结论 复方活血汤对放射损伤骨髓造血细胞增殖周期调控基因bcl-2、bax、bcl-xL有一定调节作用, 保护骨髓造血。 |
| 英文摘要: |
| Objective To explore the mechanism of and protective strategy againt bone marrow failure caused by radiation injury.Method Northern blot technique was used to detect the bcl-2, bax and bcl-xL gene expression in murine bone marrow nucleated cells (BMNC) both in Chinese drug treated group which was given per os compound blood activating decoction immediately after irradiation with 8.0 Gy 60 Co γ rays, and in control group.Results On the 3rd and 7th day after irradiation, bcl-2/bax value of BMNC decreased obviously.No bcl-xL expression was observed in control group.In Chinese drug treated group, the bcl-2/bax value increased remarkably, while bcl-xL expression occurred obviously.On the 7th day after irradiation, the bcl-2/bax value in splenic mononuclear cells was consitstent with that in BMNC in both Chinese drug treated and control groups.Conclusion Compound blood activating decoction could have a regulative effect on the expression of cell cycle regulation gene bcl-2, bax and bcl-xL in irradiated bone marrow hematopoietic cells and protect the bone marrow hematopoiesis. |
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