| 克晓燕,贾廷珍,陈旭芳,等.医源性急性放射病的临床观察[J].中华放射医学与防护杂志,1998,18(4):235-239.Ke Xiaoyan,Jia Tingzhen,Chen Xufang,et al.Clinical observation of iatrogenic acute radiation sickness[J].Chin J Radiol Med Prot,1998,18(4):235-239 |
| 医源性急性放射病的临床观察 |
| Clinical observation of iatrogenic acute radiation sickness |
| 投稿时间：1997-12-08 修订日期：1998-02-25 |
| DOI： |
| 中文关键词: 医源性急性放射病 造血干细胞 全身照射 G-CSF |
| 英文关键词:Iatrogenic acute radiation syndrome Stem cells Total body irradiation G-CSF |
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| 中文摘要: |
| 目的 观察医源性急性放射病的临床特点和治疗经验, 为事故性放射病的救治提供依据。方法 观察17例经大剂量照射预处理的PBSCT患者外周血象、体温和症状。结果 照后第8～12天, WBC均值<1×109/L, 未用G-CSF者白细胞持续此低值至13.3天, 29%的患者体温>38.5℃, 经无菌处理和强有力的抗感染治疗, 患者均能平稳渡过骨髓抑制期而不出现典型的急性放射病极期表现。结论 回输自体外周血干细胞和应用G-CSF以缩短骨髓重建时间, 严格实行全环境保护和及时、联合、足量应用抗生素的原则是PBSCT患者能够顺利渡过放射病极期, 较少合并症的关键。 |
| 英文摘要: |
| Objective Clinical observation of acute radiation sickness (ARS) induced by medical treatment in order to accumulate clinical experience .Methods The changes of peripheral blood indexes, temperature and clinical symptoms of 17 cases who were irradiated with 6.0-7.2Gy X-ray before peripheral blood stem cell transplantation (PBSCT) were observed. Results WBC counts began to decrease to below 1×109/L from 8th day after irradiation and maintained at this level for 4 days, or for 13.3 days if the patients did not receive G-CSF treatment.29.4% of patients ran a temperature higher than 38.5 ℃.After total environment protection and vigorous antibiotic treatment, all patients could successfully pass through the period of bone marrow depression without typical critical phase of ARS. Conclusion Auto peripheral blood stem cell transplantation and G-CSF treatment to reduce the time span for reconstruction of bone marrow, total environment protection and combined antibiotic treatment are the key point of sucessful treatment of PBSCT. |
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