| 李美颖,张瑶珍,张东华,等.武汉"921113"放射事故四例急性放射病人的临床报告[J].中华放射医学与防护杂志,1998,18(4):230-234.Li Mei ying,Zhang Yaozhen,Zhang Donghua,et al.Clinical report of four cases of acute radiation sickness in a 60Co radiation accident in Wuhan[J].Chin J Radiol Med Prot,1998,18(4):230-234 |
| 武汉"921113"放射事故四例急性放射病人的临床报告 |
| Clinical report of four cases of acute radiation sickness in a 60Co radiation accident in Wuhan |
| 投稿时间：1997-10-17 修订日期：1998-02-20 |
| DOI： |
| 中文关键词: 骨髓型急性放射病 辐射剂量 60Co γ射线 放射事故 |
| 英文关键词:Bone marrow form acute radiation sickness Radiation dose Cobalt-60γ-rays Radiation accident |
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| 中文摘要: |
| 目的 为了总结临床经验, 本文作者报告一起60Co γ射线事故引起4人受照的剂量估算、临床经过和诊断治疗。方法 剂量估算是采用现场模拟试验和手表红宝石热释光测量, 外周血染色体畸变率、微核率分析方法。临床诊断根据患者受照剂量, 临床表现和实验室结果进行综合分析, 治疗上在对症治疗和综合治疗的基础上, 应用了美国生产的GM-CSF.结果 1例中度(偏重)骨髓型急性放射病, 1例中度骨髓型急性放射病, 1例轻度骨髓型急性放射病。1例过量照射。4例病人经过62～68天住院积极治疗, 病情好转, 取得了良好的治疗效果。结论 从医疗实践中我们着重总结以下几点：①及时、正确地早期诊断；②根据国家标准的治疗原则积极治疗；③GM-CSF使用时注意选择时机和注意使用方法, 才能取得良好的疗效。 |
| 英文摘要: |
| Objective To sum up clinical experience from assessment of radiation dose, clinical course, diagnosis and treatment of four cases of acute radiation sickness (ARS) in a 60Co radiation accident on 13 November, 1992, in Wuhan, China.Methods Radiation doses were assessed by simulation test of accident site, thermoluminescent dosimetry of ruby, and analysis of chromosome aberration and micronuclear rates in peripheral blood.Diagnosis was based on analysis of irradiation doses, clinical manifestations and laboratory results.In therapeutical aspect, GM-CSF was administered on the basis of comprehensive treatment.Results Four cases of ARS, including 1 case of moderate degree on the severe side, 1 case of moderate degree and 1 case of mild degree bone marrow form, as well as 1 case of overexposure, were meticulously treated for 62 to 68 days. The patients' conditions took favourable turn. The therapeutic effects were good. Conclusion From the clinical point of view we stress that (1) as soon as it is possible to estimate the degree of severity of ARS accurate diagnosis should be made;(2) early comprehensive treatment should be given according to the therapeutic principles of National Standard GB8280-87;(3)to improve the curative effect, GM-CSF should be given at the right time. |
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