| 安艳,陈如松,涂开成,曹珍山,郭丰莉,李茂河.放射性碘致大鼠甲状腺损伤的形态计量学研究[J].中华放射医学与防护杂志,1998,18(3):159-163 |
| 放射性碘致大鼠甲状腺损伤的形态计量学研究 |
| Morphometric study of 131I induced injury in rat thyroid |
| 投稿时间：1996-07-18 修订日期：1997-09-22 |
| DOI： |
| 中文关键词: 放射性碘 大鼠 甲状腺 吸收剂量 形态计量学 |
| 英文关键词:Radioiodine Rats Thyroid Absorbed dose Morphometry |
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| 中文摘要: |
| 目的 为了定量测定131I 照射后大鼠甲状腺的有关组织学参数变化。方法 通过计算机图像分析系统, 采用体视学方法, 从大鼠甲状腺的腺体水平和细胞水平测定了各项形态计量学参数(包括二维和三维).结果 所测得的一些形态计量学参数随甲状腺剂量改变而增加或减少。结论 尽管在较低剂量131I 照射下, 与对照组相比, 大鼠生长发育和甲状腺功能未出现明显的差异, 但所测的各项参数与甲状腺吸收剂量之间呈现较好的剂量效应关系, 其中尤以胶体体积密度参数的变化最为明显, 其D25值和D50值为最低。 |
| 英文摘要: |
| Objectives To quantitatively measure the morphometric parameters of the strutural changes in rat thyroid irradiated with 131I .Methods By using a computerized image analysis system and the stereological method, some morphometric parameters at glandular and cellular levels including two and three dimensions can be measured successfully.Results Some morphometric parameters were gradually decreased or increased with the increase of 131I dose level.Conclusions Compared with the control group, even though there was no obvious changes in growth and function of the thyroid irradiated with low level 131I , the response of morphometric parameters was in good relationship with dose.Among the parameters, the volume density of colloid(Vvc) changed obviously and the values of D25 and D50 were the lowest. |
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