| 阮明,芦春林,章硕,尹香君.镉诱导小鼠胚胎细胞抗辐射的适应性反应及时间效应[J].中华放射医学与防护杂志,1998,18(3):151-152 |
| 镉诱导小鼠胚胎细胞抗辐射的适应性反应及时间效应 |
| Adaptive response to and its time effect on radiation induced chromosome aberrations in mouse embryonic cells pre exposed to cadmium chloride |
| 投稿时间：1997-04-01 修订日期：1997-07-24 |
| DOI： |
| 中文关键词: 适应性反应 氯化镉 60Coγ射线 小鼠胚胎 |
| 英文关键词:Adaptive response Cadmium chloride 60Co γ rays Embryonic cells |
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| 中文摘要: |
| 目的 对镉(CdCl)诱导小鼠胚胎细胞1.5Gy60Coγ射线的交叉适应性反应及时间效应进行了研究。方法 小鼠于孕9天给予氯化镉(iv)后, 分不同时间间隔给1.5Gy60Coγ射线照射, 孕10天时进行胚胎细胞染色体制备。结果 0.25～2.0mg/kg剂量的镉能诱导胚胎细胞抗辐射的交叉适应性反应, 而且与给镉后照射的时间间隔有密切关系, 4小时已显示明显适应性反应, 8小时达最高, 12, 24小时则产生协同作用。结论 氯化镉可引起交叉适应性反应并与给镉后照射时间相关。 |
| 英文摘要: |
| Objective To observe if cadmium chloride could induce cross adaptive response to and its time effect on cytogenetic damage of mouse embryonic cells caused by ionizing radiation.Methods The mice were pre treated with iv injection of cadmium chloride solution on gestation d 9, then they were exposed to 1.5cGy 60Coγ rays at different time intervals. Chromosome preparation was made on gestation d 10.Results 0.25-2.0mg Cd/kg body weight could induce resistance to cytogenetic damage of embryonic cells of mice caused by ionizing radiation and the adaptive response appeared 4 h after pre exposure, at 8h reached the peak, but 12 to 24h later synergism appeared.Conclusion Cadmium chloride could induce cross adaptive response to 60Co γ rays which had relations with time interval of ionizing radiation. |
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