| 白欧,刘树铮,牟颖.低剂量辐射对小鼠脾脏和胸腺Ⅰ型和Ⅱ型辅助性T细胞的影响[J].中华放射医学与防护杂志,1998,18(2):106-109 |
| 低剂量辐射对小鼠脾脏和胸腺Ⅰ型和Ⅱ型辅助性T细胞的影响 |
| Effect of low dose radiation on Th1 and Th2 of thymocytes and splenocytes in mice |
| 投稿时间：1997-09-08 修订日期：1997-12-28 |
| DOI： |
| 中文关键词: 低剂量辐射 Ⅰ、Ⅱ型辅助性T细胞 IFN-γ IL-6 免疫增强机理 |
| 英文关键词:Low dose radiation IFN-γ I-L 6 Th1 Th2 Immunological stimulation |
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| 中文摘要: |
| 目的 研究低剂量辐射对Ⅰ型辅助性T细胞(Th1)和Ⅱ型辅助性T细胞(Th2)的影响, 揭示低剂量辐射使Th激活的分子机理。方法 采用分子杂交方法, 检测X射线全身照射后小鼠脾脏和胸腺细胞IFN-γ和IL-6mRNA的表达。结果 75mGyX射线全身照射后小鼠脾脏和胸腺IFN-γ和IL-6mRNA表达水平明显增高。结论 低剂量辐射诱导Th1和Th2激活, 其分子机理与其启动调节Th1和Th2克隆发育的细胞因子的基因表达有关。 |
| 英文摘要: |
| Objective To elucidate the possible mechanism of activation of helper T cells after low dose radiation (LDR) exposure,the influence of whole body irradiation (WBI) with 75mGy X-rays on Th1 and Th2 was studied.Methods Mice were irradiated at a dose rate of 12.5mGy/min,and IFN-γ and IL-6 mRNA levels of the mocytes and splenocytes were analyzed by dot blot and Northern blot hybridization.Results It was found that IFN-γ and IL-6 mRNA significantly increased after WBI with 75mGyX-rays.Conclusion The gene induction of cytokine profile after LDR indicates that activation of both Th1 and Th2 subtypes may be involved in the stimulation of immune functions by LDR. |
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