| 白蕴红,王德文,崔雪梅,等.转化生长因子(TGF-β1)mRNA在放射性间质性肺炎中的表达[J].中华放射医学与防护杂志,1998,18(2):95-97.Bai Yunhong,Wang Dewen,Cui Xuemei,et al.Transforming growth factor beta 1(TGF-β1) mRNA expression in radiation interstitial pneumonitis[J].Chin J Radiol Med Prot,1998,18(2):95-97 |
| 转化生长因子(TGF-β1)mRNA在放射性间质性肺炎中的表达 |
| Transforming growth factor beta 1(TGF-β1) mRNA expression in radiation interstitial pneumonitis |
| 投稿时间：1996-01-26 修订日期：1996-05-30 |
| DOI： |
| 中文关键词: 转化生长因子 放射性间质性肺炎 原位杂交 60Coγ射线 |
| 英文关键词:TGF Radiation Interstital pneumonitis In situ hybridization |
| 基金项目:解放军总后勤部八五攻关课题 |
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| 中文摘要: |
| 目的 为探讨TGF-β1在放射性间质性肺炎中的意义和作用, 揭示其发病机理。方法 雄性Wistar大鼠48只分对照和照射组用60Coγ射线照射, 吸收剂量30Gy,于照后不同时间活杀, 取肺组织做常规病理观察和原位杂交。结果 照射组大鼠肺组织TGF-β1和正常对照组比较表达增高, 且以照射后3～6个月(纤维增生期)显着。结论 TGF-β1可能参与了放射性间质性肺炎的发生发展。 |
| 英文摘要: |
| Objective In order to study the role and significance of transforming growth factor beta 1(TGF-β1)mRNA in radiation interstitial pneumonitis (RIP),and explore the mechanism of RIP,the authors observed TGF-β1 mRNA expression in the rat lungs.Method Male Wistar rats were divided into two groups:the control and the irradiation group.The latter received thoracic irradiation of 30Gy.At 0.5,1,2,3,6 and 12 months after irradiation,rats were killed.Lung pathologic changes and expression of TGF-β1 mRNA were observed using in situ hybridization technique.Results Expression of TGF-β1 mRNA in the irradiated lungs increased,compared with that in the control group,particularly in fibrous proliferative phase(3—6 months after irradiation).Conclusion TGF-β1 is related to the development of RIP. |
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