| 范冰,鞠桂芝.0.075 Gy X射线诱导EL-4细胞凋亡及细胞周期的适应性反应[J].中华放射医学与防护杂志,1998,18(2):80-81 |
| 0.075 Gy X射线诱导EL-4细胞凋亡及细胞周期的适应性反应 |
| Adaptive response of EL-4 cells on their apoptosis and cell cycle induced by 0.075 Gy X-rays |
| 投稿时间：1997-01-14 修订日期：1997-06-02 |
| DOI： |
| 中文关键词: 电离辐射 EL-4细胞 细胞凋亡 细胞周期 适应性反应 |
| 英文关键词:Radiation EL-4 cells Apoptosis Cell cycle Adaptive response |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 观察低剂量X射线照射能否诱导EL-4细胞凋亡及细胞周期的适应性反应。方法 采用流式细胞术(FCM)检测细胞凋亡及细胞周期。结果 单纯2GyX射线照射后12小时EL-4细胞凋亡显着增多, 并伴有明显G1阻滞；0.075Gy预照射可明显减轻间隔6小时后2Gy攻击剂量照射所致的细胞凋亡和G1阻滞。结论 0.075GyX射线离体照射可诱导EL-4细胞凋亡及G1阻滞的适应性反应。 |
| 英文摘要: |
| Objective To investigate whether or not adaptive response of EL-4 cells in their apoptosis and cell cycle could be induced by low dose X-rays. Methods Flow cytometry (FCM) was employed. Results It was found that the apoptosis was enhanced by 2 Gy X-rays 12 hour after irradiation accompanied by G0/G1 phase black. However, pre-irradiation with 0.075 Gy X-rays could reduce the level of apoptosis and G0/G1 phase block induced by 2 Gy when the interval between 0.075 Gy and 2 Gy radiation was 6
hours. Conclusion 0.075 Gy pre-exposure could induce adaptive response of apotosis and G1 arrest in EL-4 cells. |
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