| 李津婴,章卫平,刘本俶.辐射对人红细胞酶损伤的远后效应[J].中华放射医学与防护杂志,1998,18(1):36-38 |
| 辐射对人红细胞酶损伤的远后效应 |
| Delayed effects of radiation on enzymes in erythrocytes |
| 投稿时间：1997-04-15 修订日期：1997-05-20 |
| DOI： |
| 中文关键词: 辐射损伤 远后效应 红细胞 酶活力 |
| 英文关键词:Radiation damage Delayed effect Erythrocytes Enzyme activity |
| 基金项目: |
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| 中文摘要: |
| 目的 研究辐射对红细胞酶损伤的远后效应。方法 对5例骨髓型急性放射病病人受照后第1, 2, 3, 6年分别进行五大类代谢途径8种红细胞酶活力动态观察。结果 受照后初期活力低下的酶G6PD、PK、MR及恢复期活力下降的酶ACE在后续4次测定中均有不同程度回升, 但个别患者的上述前三种酶活力始终低于正常下限。受照剂量、患者年龄与酶活力变化之间无显着相关性。结论 辐射对红细胞酶损伤的远后效应在糖酵解酶PK、已糖旁路酶G6PD和氧化还原代谢酶MR表现最为明显。结果 提示, 辐射可能损伤了参与酶合成的相关基因。 |
| 英文摘要: |
| Objective To study the delayed effects of radiation on the enzymes in erythrocytes.Methods The activity of 8 enzymes, related glycolysis, hexose monophosphate shunt, nucleotide metabolism, redox reaction and esterase in erythrocytes of five patients with bone marrow form of acute radiation sickness(ARS) were assayed at 1, 2, 3 and 6 years after exposure to 60 Co radiation. Results The decreased activities of glucose 6 phosphate dehydrogenase(G6PD), pyruvate kinase(PK), NADH methemoglobin reductase (MR) during the stage of crisis and of acetylcholinesterase (ACE) during the stage of convalescence were recovered to varying extent, whereas the lowered activities of the first three enzymes in some cases remained unchanged.There was no correlation between the enzyme activity and the radiation dose as well as the age of the patients. Conclusion It is demonstrated that the delayed effects of radiation damage to erythrocyte enzymes are most significant in PK of glycolosis, G6PD of hexose monophosphate shunt and MR of redox reaction.It is suggested that the genes related to the synthesis of erythrocyte enzymes may be damaged by radiation. |
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