中华放射医学与防护杂志

郭峰,张俊洁,赵书平,承建国.五例急性放射病病人红细胞CR1数量基因表达及活性随访实验研究[J].中华放射医学与防护杂志,1998,18(1):33-35

五例急性放射病病人红细胞CR1数量基因表达及活性随访实验研究

Following up laboratory study for erythrocyte CR-1 quantity gene expression and activity in five patients with acute radiation sickness

投稿时间：1997-04-15 修订日期：1997-05-20

DOI：

中文关键词: 急性放射病红细胞免疫功能补体受体Ⅰ型基因

英文关键词:Acute radiation sickness Red cell immune function CR1 gene

基金项目:

作者	单位
郭峰	200433 上海, 第二军医大学长海医院
张俊洁	200433 上海, 第二军医大学长海医院
赵书平	200433 上海, 第二军医大学长海医院
承建国	200433 上海, 第二军医大学长海医院

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中文摘要:

目的研究中、重度骨髓型急性放射病病人红细胞免疫功能变化规律。方法用PCR法研究红细胞CR1数量基因的变化, 用红细胞C₃b受体花环试验研究红细胞CR1活性变化。结果 5例放射病病人的红细胞CR1数量基因无变化, 而红细胞CR1活性明显低于正常值。在事故发生后4.5年红细胞CR1活性才恢复正常。结论结果说明放射病病人红细胞CR1活性的变化是长期的。

英文摘要:

Objective To study the change regularity of red cell immune function in patients with moderate or severe acute radiation sickness (ARS). Methods Polymerase chain reaction (PCR) was used to study the change of erythrocyte CR1 quantity gene (ECR1 gene).Red cell C₃b receptor rosette test (RC₃bRT) was used to study the change of ECR1 activity. Results ECR1 gene was not changed in ARS.And ECR1 activity in ARS (5 cases) was significantly lower than in normal people.ECR1 activity in ARS was increased to normal in four and a half years after the accidental radiation exposure. Conclusions These results indicate that change of ECR1 activity in ARS exists for long time.

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