| 闵锐,沈茜,刘本俶,陈杞,孟祥顺,杨如俊,肖锦松,郭明珠,董俊瑞.急性放射病患者恢复期外周血淋巴细胞表型及功能分析[J].中华放射医学与防护杂志,1998,18(1):26-29 |
| 急性放射病患者恢复期外周血淋巴细胞表型及功能分析 |
| Analysis of phenotype and function of peripheral blood lymphocytes for patients with acute radiation sickness during recovery stage |
| 投稿时间：1997-04-15 修订日期：1997-05-20 |
| DOI： |
| 中文关键词: 急性放射病 T淋巴细胞表型 淋巴细胞功能 恢复期 |
| 英文关键词:Acute radiation sickness T cell phenotype Lymphocyte function Recovery stage |
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| 中文摘要: |
| 目的 了解急性放射病患者恢复期间外周血淋巴细胞功能。方法 用流式细胞仪分析淋巴细胞表型, 3H-TdR掺入法分别分析T细胞和NK细胞功能。结果 照后4.5年, 患者外周血CD4+T细胞仍有不同程度低于正常对照； 受照剂量大于2Gy者CD8+T细胞数明显高于正常, 而受照时年龄为54岁者CD8+T细胞明显低于对照； 多数患者外周血NK细胞数和功能都高于正常对照。 |
| 英文摘要: |
| Objective To research the peripheral blood lymphocyte functions in patients with acute radiation sickness during recovery stage. Methods Phenotype of lymphocytes was analysed with flow cytometry;the functions of T cells and NK cells were analysed by biological method through determination of 3H TdR incorporation. Results At four and a half years after radiation exposure the CD4+ T cell counts in patients' peripheral blood was still lower than those in normal controls;the patients whose exposure dose was over 4 Gy showed higher PB CD8+ T cell counts but a patient exposed at the age of 54 years showed obviously lower counts;during restoration, all patients had enhanced CD + 16 cell count and NK cell function. Conclusion The restoration of T cell functions for the patients seemed associated with exposure dose and patients' age at the time of exposure;the enhancement in the number and activity of the NK cells for the patients during restoration may play a significant role in cellular immune recovery. |
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