| 金璀珍,刘秀林,张泽云,骆亿生.上海“6.25”60Co源事故受照者照后4～6年细胞遗传学随访观察[J].中华放射医学与防护杂志,1998,18(1):21-25 |
| 上海“6.25”60Co源事故受照者照后4～6年细胞遗传学随访观察 |
| A cytogenetic follow up study of five victims accidentally exposed to 60Co γ-rays |
| 投稿时间：1997-04-15 修订日期：1997-05-20 |
| DOI： |
| 中文关键词: 染色体核型分析 辐射事故 稳定性畸变 |
| 英文关键词:Chromosome karyotype analysis Radiation accident Stable type aberrations |
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| 中文摘要: |
| 目的 用染色体核型分析方法对上海6.25钴源事故5名受照者照后4～6年进行随访观察, 为评价辐射对人远期健康影响提供生物学依据。方法 照后第4年用常规染色方法, 照后第5年用G显带法, 照后第6年进而用染色体核型自动分析系统, 加大分析细胞数, 使结果更精确。结果 根据照后4～6年的随访观察结果, 证实在这些受照者所见到的畸变主要是稳定性畸变, 它们的频率与原先所受剂量大小关系密切。 |
| 英文摘要: |
| Objective A radiation accident involving a 60Co source occurred in Shanghai in June, 1990 in which five victims were exposed to moderate to high doses (2.0-5.2Gy).Cytogenetic study was extended over 4-6 years after irradiation as one of the major long term follow up surveys to evaluate biological effects of radiation. Method Chromosome slides were prepared using conventional Giemsa stain and G banding method for the karyotype analysis. Results Chromosome analyses revealed that most of remaining aberrations were of stable types and they contributed the major evidence of a dose response relationship. Conclusion These findings provide information that Cs type aberrations are useful for assessing the dose response relationship in those persons who were irradiated many years before cytogenetic examination. |
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