| 宋良文,王德文,崔雪梅,等.铁、牛磺酸和精氨酸对大鼠肝纤维化的影响[J].中华放射医学与防护杂志,1997,17(6):410-413.Song Liangwen,Wang Dewen,Cui Xuemei,et al.Effect of iron,taurine and arginine on rat hepatic fibrosis[J].Chin J Radiol Med Prot,1997,17(6):410-413 |
| 铁、牛磺酸和精氨酸对大鼠肝纤维化的影响 |
| Effect of iron,taurine and arginine on rat hepatic fibrosis |
| 投稿时间：1996-06-24 修订日期：1996-11-13 |
| DOI： |
| 中文关键词: 放射性肝纤维化 铁剂 丙二醛 羟脯氨酸 牛磺酸 精氨酸 |
| 英文关键词:Radiation hepatic fibrosis Taurine Iron agent Hydroxyproline Malondialdehyde L-arginine |
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| 中文摘要: |
| 目的 应用放射性大鼠肝纤维化模型探讨铁剂在放射性肝纤维化发生中的作用及牛磺酸和精氨酸对肝脏的保护作用。方法 将大鼠分为0Gy(正常对照)、30Gy和30Gy+铁剂、30Gy+牛磺酸和30Gy+精氨酸组。于肝区照射后1,3个月分别检测血清铁离子、肝组织羟脯氨酸(Hyp)和丙二醛(MDA)含量以及应用偏振光显微镜观察肝内Ⅰ、Ⅲ胶原纤维的生成及分布特点。结果 铁剂能明显增加肝组织中MDA的含量和血清铁离子浓度。照射后1个月,铁剂组肝组织中Hyp开始明显增加,进而肝脏中胶原纤维产生增多。牛磺酸和精氨酸能明显降低血清铁离子浓度,减少肝组织Hyp含量。结论 外源性铁剂能促进放射性肝纤维化的早期发生；牛磺酸和精氨酸可分别在一定程度上减轻放射性肝纤维化的病变 |
| 英文摘要: |
| Objective The promotive role of iron on pathogenesis of hepatic fibrosis and the protective role of taurine and L-arginine against hepatic fibrosis were studied.Methods The model of rat radiation hepatic fibrosis was used.Experimental rats were divided into 0Gy,30Gy,30Gy+iron,30 Gy+taurine and 30Gy+L arginine groups.Serum iron,liver tissue hydroxyproline(Hyp) and malondialdehyde (MDA) were measured one and three months respectively after irradition of hepatic tissue,production and distribution characteristics of hepatic tissne type Ⅰ and Ⅲ collagen were observed with a polarizing microscope.Results Administration of iron agent could significantly increase hepatic tissue MDA content and serum iron concentration,one month after irradiation ,hepatic tissue Hyp in 30Gy+iron group began to increase,and collagen in hepatic tissue obviously increased.Taurine and L arginine could reduce serum iron concentration and decrease production of hepatic fissue Hyp.Conclusion Exogenous iron agent could promote early development of radiation hepatic fibrosis;taurine and arginine could diminish pathologic alteration of hepatic fibrosis to a certain extent. |
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