| 李晓瑛,赵坡,王德文,等.人慢性放射性皮肤溃疡中端粒酶活性升高[J].中华放射医学与防护杂志,1997,17(6):408-409.Li Xiaoying,Zhao Po,Wang Dewen,et al.Elevation of telomerase activity in chronic radiation ulcer of human skin[J].Chin J Radiol Med Prot,1997,17(6):408-409 |
| 人慢性放射性皮肤溃疡中端粒酶活性升高 |
| Elevation of telomerase activity in chronic radiation ulcer of human skin |
| 投稿时间：1996-09-23 修订日期：1996-12-16 |
| DOI： |
| 中文关键词: 放射性皮肤溃疡 端粒酶 癌 |
| 英文关键词:Radiation skin ulcer Telomerase Cancer |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的 探讨人慢性放射性皮肤溃疡中端粒酶活性状况及其与癌变的可能关系。方法 应用非同位素端粒重复序列扩增技术检测20例人慢性放射性皮肤溃疡,5例正常皮肤,5例癌组织。结果 放射性皮肤溃疡端粒酶活性升高阳性率为30.0%(6/20);正常皮肤组织为阴性(0/5);癌组织阳性率为100%(5/5),放射性皮肤溃疡的端粒酶活性强度稍弱于癌组织。结论 端粒酶活性测定可能成为判定慢性放射性皮肤溃疡预后和治疗效应的标志 |
| 英文摘要: |
| Objective To investigate the levels of telomerase activity in chronic radiation ulcers of human skin and the possible relationship between the enzyme and cancer transformation.Method Using nonisotopic telomere repeat amplification protocol (TRAP),detections were performed in 20 cases of chronic radiation ulcers of human skin,5 cases of normal skin tissues and 5 cases of carcinoma.Results The positive rates for telomerase activity were 30.0% (6/20),0(0/5) and 100%(5/5) in chronic radiation ulcers of human skin,normal skin and carcinoma,respectively.The telomerase activity in radiation ulcer was weaker than in carcinoma.Conclusion The telomerase activity assay might be used as a marker for predicting the prognosis and the effect of treatment in chronic radiation ulcer of human skin. |
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