| 邹剑明,姚军,陈念光,等.阳江高本底地区居民中免疫水平与对病毒免疫反应的研究[J].中华放射医学与防护杂志,1997,17(6):399-403.Zou Jianmin,Yao Jun,Chen Nianguang,et al.Studies on immune competence and immune response to virus in inhibitants of high background radiation area (HBRA),Yangjiang,China\[J].Chin J Radiol Med Prot,1997,17(6):399-403 |
| 阳江高本底地区居民中免疫水平与对病毒免疫反应的研究 |
| Studies on immune competence and immune response to virus in inhibitants of high background radiation area (HBRA),Yangjiang,China\ |
| 投稿时间：1997-06-03 修订日期：1997-09-04 |
| DOI： |
| 中文关键词: 高本底辐射 白细胞介素－2分泌细胞 乙型肝炎病毒 EB病毒 免疫功能 |
| 英文关键词:High background radiation Interleukin 2 secreting cells EB virus Hepatitis B virus Immune function |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨在天然高本底电离辐射作用下机体的免疫水平与对病毒的免疫反应。方法 利用单克隆抗体APAAP法检测白细胞介素-2分泌细胞(IL-2SC);利用间接免疫酶法检测抗EB病毒抗原抗体水平(VCA/IgA,VCA/IgG,EA/IgA,EA/IgG);采用酶标免疫吸附沉淀法检测乙型肝炎(HBV)表面抗原(HBsAg),表面抗原抗体(HBsAb)和核心抗体(HBcAb).结果高本底地区(HBRA)居民外周血淋巴细胞IL-2SC频数显着高于对照(CA);VCA/IgA、VCA/IgG、EA/IgG抗体水平均高于CA,但仅VCA/IgG抗体滴度水平存在差异显着性,两地区VCA/IgA≥15阳性检出率均显着高于广东地区的平均水平；HBV感染率与HBsAb阳性率为HBRA高于CA(P>0.05).结论 提示长期低水平电离辐射作用机体免疫功能有增强的趋势。 |
| 英文摘要: |
| bjective Immune competence and immune response to virus of inhabitants after long term exposure to low level radiation were explored. Methods Using the monoclonal antibody APAAP method interleukin-2 secreting cells (IL-2SC) were examined.The levels of anti EBV antibodies titers (including VCA/IgA,VCA/IgG,EA/IgA and EA/IgG) were inspected by the indiect immunoenzymatic assay.Using ELISA method,the evaluation indexes of infection rate of hepatitis B virus (such as HBsAg,HBsAb and HBcAb) were observed.Results The frequency (%) of PBL-IL-2SC was signiticantly increased in subjects from HBRA compared to those in the control area (CA).The levels of anti EBV antibodies,including VCA/IgA,VCA/IgG and EA/IgG,were higher in HBRA than in CA,but there was significant difference only in the geometric mean of titer of VCA/IgG between HBRA and CA;for the rate of positive titer detection of VCA/IgA(≥1.5) in these two areas,they were significantly higher than those in Guangdong Province.Both the infection rate of HBV and the positive rate of HBsAb were higher in HBRA than in CA; however,no significant difference existed between them.Coclusion It is suggested that there is a tendency that the immune function is increased after exposure to low level radiation for a long time. |
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