中华放射医学与防护杂志

陈德清,姚素艳,张朝阳,等.阳江高本底辐射对不同年龄居民染色体畸变的影响[J].中华放射医学与防护杂志,1997,17(6):386-389.Chen Deqing,Yao Suyan,Zhang Chaoyang,et al.Cytogenetic findings from inhabitants of different ages in high background radidation areas of Yangjiang\[J].Chin J Radiol Med Prot,1997,17(6):386-389

阳江高本底辐射对不同年龄居民染色体畸变的影响

Cytogenetic findings from inhabitants of different ages in high background radidation areas of Yangjiang\

投稿时间：1997-06-11 修订日期：1997-08-29

DOI：

中文关键词: 高本底辐射染色体畸变淋巴细胞

英文关键词:High background raidation Chromosome aberrations Lymphocytes

基金项目:

作者	单位
陈德清	100088 北京, 卫生部工业卫生实验所
姚素艳	100088 北京, 卫生部工业卫生实验所
张朝阳	100088 北京, 卫生部工业卫生实验所
戴连连	100088 北京, 卫生部工业卫生实验所
姜涛	100088 北京, 卫生部工业卫生实验所
王春燕	100088 北京, 卫生部工业卫生实验所
李曙	100088 北京, 卫生部工业卫生实验所
袁镛龄	湖南省劳动卫生研究所
魏履新	100088 北京, 卫生部工业卫生实验所
中井斌	日本体质研究会
菅原努	日本体质研究会

摘要点击次数: 4265

全文下载次数: 2041

中文摘要:

目的探讨高本底辐射对人体损伤的剂量效应关系。方法从阳江高本底辐射地区(HBRA)选择10,40,55和70岁居民,采集外周血用微量全血培养,常规方法制备染色体标本。结果 HBRA居民伴有断片的双着丝粒显着高于对照(CA)(0.77‰与0.28‰,P<0.01),总的结构性畸变也显示HBRA显着高于CA(4.69‰与3.15‰,P<0.01),并且随年龄(或累积剂量)而增加,呈线性关系。结论染色体畸变是极其灵敏的辐射损伤指征和辐射生物剂量计。

英文摘要:

Objective To explore the relationship between high background radiation and injurious effect on inhabitants. Method Peripheral blood samples were collected from the inhabitants of 10, 40, 55 and 70 years old in high background radiation areas (HBRA) of Yangjiang, Chromosome preparations were carried out with conventional whole blood microculure. Results The percentage of dicentric chromosome with fragments in inhabitants of HBRA was significantly higher than that in control areas (CA) (4.69‰ vs. 3.15‰, P<0.01), and there was an increase in the aberration frequencies with age (or accumulated doses). Conclusion Chromosome aberration is an extremely sensitive indicator of radiation damage and a good radio biodosimeter.

HTML 查看全文查看/发表评论下载PDF阅读器

关闭