中华放射医学与防护杂志

敖琳,曹佳,程天民,等.放烧复合伤诱导小鼠骨髓红细胞微核率的研究[J].中华放射医学与防护杂志,1997,17(5):309-311.Ao Lin,Cao Jia,Cheng Tianmin,et al.Frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow induced by combined radiation burn injury[J].Chin J Radiol Med Prot,1997,17(5):309-311

放烧复合伤诱导小鼠骨髓红细胞微核率的研究

Frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow induced by combined radiation burn injury

投稿时间：1996-01-10 修订日期：1996-07-05

DOI：

中文关键词: 微核放烧复合伤小鼠骨髓

英文关键词:Micronuclei Combined radiation burn injury Mice Bone marrow

基金项目:

作者	单位
敖琳	630038 重庆, 第三军医大学预防医学系
曹佳	630038 重庆, 第三军医大学预防医学系
程天民	630038 重庆, 第三军医大学预防医学系
杨录军	630038 重庆, 第三军医大学预防医学系
钱频	630038 重庆, 第三军医大学预防医学系
刘胜学	630038 重庆, 第三军医大学预防医学系

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中文摘要:

目的探讨放烧复合伤条件下,小鼠骨髓嗜多染红细胞MN率(fMPCE)用于估算辐射剂量的可能性。方法以fMPCE为指标,实验分为单纯烧伤组(10%,20%),单纯放射组(1,3,5Gy),放烧复合伤组(10%+1,3,5Gy,20%+1,3,5Gy),研究fMPCE在24小时的量效关系。结果单纯烧伤组与空白对照组相比,fMPCE均无明显增加,放烧复合伤各剂量组明显低于单放组,烧伤面积20%放烧复合伤组又明显低于10%放烧复合伤组。结论小鼠放射损伤复合烧伤后其骨髓fMPCE呈降低趋势,研究还发现烧伤后小鼠骨髓新生红细胞(PCE)比例有一定升高,这可能是造成放烧复合伤时fMPCE降低的原因。

英文摘要:

Objective In order to detect if any analysis of frequency of micronucleated polychromatic erythrocytes (fMPCE) in mouse bone marrow was possible to diagnose combined radiation burn injuries. Methods By using the index of fMPCE, the investigation was carried out in the conditions of burn injury alone, radiation injury alone and combined radiation-burn injury. Results The fMPCE induced by 10% and 20% body surface area (BSA) burns were not significantly increased at 24h compared with untreated groups. The fMPCE induced by combined radiation burn injury significantly lower that those by radiation alone, and the fMPCE in the 20% BSA combined radiation-burn injury groups were lower than those in 10% BSA group. Conclusion These results indicate that radiation combined burns have an effect to reduce the fMPCE induced by radiation injury. The reason may be due to the frequency of increase of PCE after burn injury.

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