| 王荣先,李美佳,庄湘莲,等.抗辐射药物2,2-二甲基四氢噻唑及胱胺有机酸盐的研究[J].中华放射医学与防护杂志,1997,17(4):250-252.Wang Rongxian,Li Meijia,Zhuang Xianglian,et al.Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine[J].Chin J Radiol Med Prot,1997,17(4):250-252 |
| 抗辐射药物2,2-二甲基四氢噻唑及胱胺有机酸盐的研究 |
| Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine |
| 投稿时间：1996-05-28 修订日期：1996-10-04 |
| DOI： |
| 中文关键词: 抗辐射药物 四氢噻唑 胱胺 |
| 英文关键词:Radioprotective agent Thiazolidine Cystamine |
| 基金项目: |
|
| 摘要点击次数: 3394 |
| 全文下载次数: 1952 |
| 中文摘要: |
| 目的 为了改善2,2-二甲基四氢噻唑盐酸盐(DMTD)的理化性质及提高辐射防护效价。方法 合成了DMTD和胱胺的各种有机酸盐, 对9.03Gy60Coγ射线一次全身照射的小鼠, 照前给药, 评价它们的辐射防护效果。结果 大部分化合物具有不同程度的防护效果, 其中DMTD酒石酸盐250mg/kg,照前一小时腹腔注射, 存活率比单独照射对照组提高40%;胱胺琥珀酸盐250mg/kg,照前15分钟腹腔注射, 存活率净增加77.5%.结论 胱胺琥珀酸盐的辐射防护效果显着, 值得进一步研究。 |
| 英文摘要: |
| bjective To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the antiradiation effect. Methods Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized.The drug was administered to mice before 9.03 Gy 60Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results Most of these compounds showed significant radioprotective effects.Among them,DMTD tartrate 250mg/kg given i.p.1 hour before irradiation increased the survival rate by 40%.Cystamine succinate 250mg/kg administered i,p.15 min.before irradiation increased the survival rate by 77.5%. Conclusion Cystamine succinate showed marked antiradiation effect.Further investigation is worthwhile. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|