| 金敖兴,汪思应,魏道严,黄帼.低水平全身照射抑制B16黑色素瘤血道肺转移的机理研究[J].中华放射医学与防护杂志,1997,17(4):236-238 |
| 低水平全身照射抑制B16黑色素瘤血道肺转移的机理研究 |
| Mechanism of low level ionizing radiation in inhibiting B16 melanoma blood borne pulmonary metastasis |
| 投稿时间：1996-12-19 修订日期：1997-04-17 |
| DOI： |
| 中文关键词: 低水平电离辐射 B16黑色素瘤细胞 清除率 免疫功能 |
| 英文关键词:Low level ionizing radiation B16-melanoma cells Clearance Immune function |
| 基金项目:国家自然科学基金 |
|
| 摘要点击次数: 2676 |
| 全文下载次数: 1672 |
| 中文摘要: |
| 目的 探讨低水平照射抑制B16黑色素瘤血道肺转移的机理。方法 用125I标记B16黑色素瘤细胞, 观察了低剂量照射对小鼠体内B16细胞的分布及清除率的影响。结果 7.5cGyX射线单次全身照射后, 小鼠肺各时相对肿瘤细胞清除率较对照组有明显提高(P<0.01),存留于血、肺、肝、脾中的标记肿瘤细胞量减少；与此同时, 照后24小时检测小鼠免疫功能发现, 小鼠脾细胞NK活性、淋巴细胞转化率(LTR)及巨噬细胞(Mф)吞噬功能明显增强。结论 7.5cGyX射线照射可通过增强NK细胞、巨噬细胞吞噬功能而加速肺内肿瘤细胞的清除率。 |
| 英文摘要: |
| bjective To study the mechanism of low level ionizing radiation in inhibiting B16 melanoma blood borne pulmonary metastasis. Method 125I labelled B16 melanoma cells were used to investigate the effect of low dose X irradiation on the distribution and clearance of tumor cells in mice. Results After whole body 7.5 cGy X-irradiation,the clearance of tumor cells was siginificantly increased from lungs of mice.The residual numbers of tumor cells were markedly lower than those of control in blood,spleen,liver and lungs (P<0.05-0.01).The cytotoxicity of murine splenic NK cells,LTR and the phagocytosis of macrophages augmented significantly after the mice were irradiated with low dose X-rays. Conclusion These results suggest that the enhancement of NK cytotoxicity and macrophage phagocytotic function might be one of the important reasons why low dose radiation can accelerate the clearance of tumor cells from the lungs. |
| HTML 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |